Medications and Drugs
GENERIC NAME: lansoprazole
BRAND NAME: Prevacid
DRUG CLASS AND MECHANISM: Lansoprazole is in a class of drugs called proton pump inhibitors (PPI) which block the production of acid by the stomach. Other drugs in the same class include rabeprazole
(Aciphex), omeprazole (Prilosec), pantoprazole (Protonix), and esomeprazole (Nexium). Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison
syndrome that are caused by stomach acid. Lansoprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal.
GENERIC AVAILABLE: Yes, No (Prevacid OTC)
PRESCRIPTION: Yes
PREPARATIONS: Capsules: 15 and 30 mg. Oral suspension:
in 15 and 30 mg unit dose cartons of 30. Lansoprazole also is available in 15 and 30 mg tablets that disintegrate when placed under the tongue (Prevacid SoluTab). Lansoprazole is available for intravenous injection in vials containing 30 mg of powdered lansoprazole (30 mg/5 ml when mixed
with sterile water).
STORAGE: Store at room temperature, 15-30 C (59-86 F). Keep away from moisture.
PRESCRIBED FOR: Lansoprazole is used for treating ulcers of the stomach and duodenum, gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome.
DOSING: For initial treatment of duodenal ulcers the recommended dose for adults is 15 mg daily for 4 weeks. For the treatment of GERD, the recommended initial treatment is 15 mg for up to 8 weeks. For maintaining healing (long-term) in duodenal ulcer and GERD the recommended treatment is 15 mg daily. For initial treatment of severe
(erosive) esophagitis and gastric ulcer, the recommended dose for adults is 30 mg daily for 4-8 weeks. For the management of Zollinger-Ellison Syndrome, the starting dose for adults is 60 mg daily, and the dose is adjusted based on response. Doses up to 180 mg have been used in some patients with
Zollinger-Ellison syndrome.
Intravenous lansoprazole is approved for patients who are unable to
take oral lansoprazole. The approved intravenous dose is 30 mg daily for
up to 7 days.
It is recommended that capsules be taken before meals for maximum effect. Capsules should be swallowed whole and should not be crushed, split or chewed.
DRUG INTERACTIONS: Lansoprazole is less likely than omeprazole to interact with other drugs.
The absorption of certain drugs may be affected by stomach acidity, and, as a result, lansoprazole and other PPIs that reduce stomach acid also reduce the absorption and concentration in blood of ketoconazole
(Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, respectively.
PREGNANCY: Use of lansoprazole in
pregnant women has not been adequately evaluated.
NURSING MOTHERS: Lansoprazole has not been studied in
nursing women.
SIDE EFFECTS: Lansoprazole like other PPIs is well-tolerated. The most common side effects are diarrhea, nausea,
vomiting, constipation, rash and
headaches.
Dizziness, nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention rarely occur.
Reference: FDA Prescribing Information
Last Editorial Review: 3/9/2003
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
- Drug Interactions - Learn about potential drug interactions you may be exposed to. Drug interactions can occur with prescription drugs, OTC medication, vitamins, herbs, and supplements.
- Esophageal pH Monitoring - Esophageal pH monitoring is a procedure for measuring the reflux (regurgitation or backwash) of acid from the stomach into the esophagus. The Esophageal pH test is used to diagnose GERD.
- Gastroesophageal Reflux Disease (GERD, Heartburn) - Learn about gastroesophageal reflux disease (GERD, acid reflux, heartburn) symptoms like heartburn, chest pain, regurgitation, and nausea. Causes, diagnosis, treatment and prevention information is also included.
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