lamotrigine, Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: The most common side effects reported by patients taking lamotrigine are dizziness, somnolence, headache, double vision, blurred vision, nausea, vomiting, and rash. Severe, life-threatening rashes have occurred with lamotrigine. The risk of rash is increased if the dose is increased faster than recommended or if patients also are taking valproic acid. Patients taking lamotrigine should report any rash to a physician immediately. Multiorgan failure, including fatal liver disease rarely has been observed during lamotrigine treatment.

Reduced white blood cells, red blood cells, and platelets also may occur.

Lamotrigine increases the risk of developing aseptic meningitis.

As a general rule, anti-seizure medications should not be abruptly stopped because of the possibility of increasing the frequency of seizures. In most cases, the dose of lamotrigine should be gradually lowered over a period of at least two weeks. Antiepileptic medications have been associated with an increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need for the drugs. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.

Reference: FDA Prescribing Information


Last Editorial Review: 3/1/2012



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