lamotrigine, Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR

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GENERIC NAME: lamotrigine

BRAND NAME: Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR

DRUG CLASS AND MECHANISM: Lamotrigine is an oral drug that is used primarily for treating seizures. It is chemically unrelated to other anti-seizure drugs. The precise mechanism by which lamotrigine exerts its anti-seizure action is not known. The FDA approved lamotrigine in December 1974.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS:

  • Tablets: 25, 100, 150, and 200 mg.
  • Tablets, chewable (CD): 2, 5, and 25 mg.
  • Tablets, orally disintegrating (ODT): 25, 50, 100, and 200 mg.
  • Tablets, extended release (XR): 25, 50, 100, 200, 250, and300 mg.

STORAGE: Tablets should be stored at room temperature, between 15-30 C (59-86 F).

PRESCRIBED FOR: Lamotrigine is used in combination with other anti-seizure drugs for the treatment of partial seizures, tonic-clonic seizures, and seizures of Lennox-Gastaut syndrome. It also is used alone for treating partial seizures in patients 16 years and older when converting from other anti-epileptic drugs. Lamotrigine also is used for preventing mood episodes in individuals 18 years or older with bipolar disorder.

DOSING: The dose of immediate release lamotrigine for seizures in patients not taking valproic acid (Depakote, Depakote ER, Depakene, Depacon, Stavzor), but taking seizure medications that reduce lamotrigine blood levels (for example, phenobarbitol, phenytoin [Dilantin, Dilantin-125], carbamazepine [Tegretol], primidone) is 50 mg once daily for two weeks, followed by 100 mg daily given in two divided doses for two weeks. Thereafter, the dose is increased by 100 mg daily every 1-2 weeks up to the usual maintenance dose of 300 to 500 mg daily given as a divided dose.




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