lamivudine and zidovudine, Combivir (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
The effectiveness of either lamivudine or zidovudine when used alone may decrease as the HIV virus develops resistance to the effects of the individual drugs. By combining lamivudine and zidovudine, it is more difficult for the HIV virus to develop resistance to therapy since it must develop resistance to both drugs. As a result, Combivir is more effective than lamivudine or zidovudine alone. Combivir does not kill existing HIV virus, and it is not a cure for HIV. Combivir was approved by the FDA in September 1997.
PRESCRIBED FOR: Combivir is used, in combination with other agents, for the treatment of HIV infection.
SIDE EFFECTS: The most serious side effects of Combivir are:
Other side effects include
Accumulation or redistribution of fat also may occur.
GENERIC AVAILABLE: Yes.
PREPARATIONS: Tablets: 150/300 mg (lamivudine/zidovudine)
STORAGE: The tablets should be stored at 2 C to 30 C (36 F to 86 F).
DOSING: For the treatment of HIV infection the recommended oral dose for adults or children weighing 30 kg or more is one tablet twice daily. Combivir is administered without regard to meals since food does not affect its absorption.
Medically Reviewed by a Doctor on 7/9/2015
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