lamivudine and zidovudine, Combivir (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PREGNANCY: Use of Combivir during pregnancy has not been adequately evaluated.

NURSING MOTHERS: Use of Combivir by nursing mothers has not been studied. Lamivudine and zidovudine are excreted in breast milk. HIV infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected.

SIDE EFFECTS: The most serious side effects of Combivir are a decrease in blood cells, muscle pain (myopathy) or muscle breakdown (rhabdomyolysis), pancreatitis, liver enlargement, fatty liver, hypersensitivity reactions, and metabolic disturbance (lactic acidosis). Other side effects include chills, rash, abdominal pain, nausea and vomiting, weight loss, headache, cough, and insomnia. Accumulation or redistribution of fat also may occur.

Reference: FDA Prescribing Information

Last Editorial Review: 9/6/2012

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