lamivudine, Epivir; Epivir HBV (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Lamivudine is used for the treatment of HIV infection and hepatitis B infection. It also is used off-label for prevention of HIV among individuals accidentally exposed to HIV.

SIDE EFFECTS: The most severe side effects of lamivudine are:

  • pancreatitis,
  • liver failure,
  • metabolic disturbance (lactic acidosis),
  • a decrease in blood cells,
  • muscle pain,
  • weakness, and
  • nerve damage in the extremities (peripheral neuropathy). Symptoms of peripheral neuropathy are tingling, numbness and pain in the feet or hands.

Other important side effects are

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 100, 150, and 300 mg; oral solution: 5, 10 mg/ml

STORAGE: Tablets and solution should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

DOSING: For the treatment of HIV infection the recommended dose for adults is 150 mg twice daily or 300 mg once daily for those weighing 50 kg or more and 4 mg/kg twice daily (not to exceed 150 mg twice daily) if less than 50 kg.

Neonates are treated with 2 mg/kg twice daily.

Children (1 month to 16 years old) should be treated with 4 mg/kg twice daily up to a maximum dose of 300 mg daily. Children (<16 years old) weighing less than 50 kg should receive 4 mg/kg twice daily up to a maximum dose of 300 mg daily. Children (>16 years old) weighing 50 kg or more should receive 150 mg twice daily or 300 mg daily.

Medically Reviewed by a Doctor on 7/9/2015


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