GENERIC NAME: lamivudine (3tc)
BRAND NAME: Epivir, Epivir HBV
GENERIC AVAILABLE: Yes
- Lamivudine is used for the treatment of HIV infection and hepatitis B virus (HBV) infection.
- It also is used off-label for prevention of HIV among individuals accidentally exposed to HIV.
WARNING: (BLACK BOX WARNING):
- Lactic acidosis, severe hepatomegaly with steatosis, including fatal cases, may occur from use of lamivudine.
- Severe acute flare up of hepatitis B has been reported in patients infected with hepatitis B virus and human immunodeficiency virus after stopping lamivudine. Liver function should be monitored in these patients and anti-hepatitis B treatment should be started if needed.
- The dose for treating HIV infection is different from the dose for treating hepatitis B infection.
The most severe side effects of lamivudine are:
- liver failure,
- metabolic disturbance (lactic acidosis),
- a decrease in blood cells,
- muscle pain,
- weakness, and
- nerve damage in the extremities (peripheral neuropathy). Symptoms of peripheral neuropathy are tingling, numbness and pain in the feet or hands.
Other important side effects are
Quick GuideHIV AIDS Facts: Symptoms and Treatments
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