labetalol, Normodyne, Trandate

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GENERIC NAME: labetalol

BRAND NAMES: Normodyne (Discontinued Brand), Trandate

DRUG CLASS AND MECHANISM: Labetalol is a drug that is used for treating high blood pressure. And is related to carvedilol (Coreg). Nerves from the adrenergic nervous system travel from the spinal cord to arteries where they release norepinephrine. Norepinephrine attaches to adrenergic receptors on arteries and causes the arteries to contract, narrowing the arteries, and increasing blood pressure. Labetalol blocks receptors of the adrenergic nervous system. When labetalol attaches to and blocks the receptors, arteries expand, resulting in a fall in blood pressure. The FDA approved labetalol in August 1984.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATION: Tablets: of 100, 200 and 300 mg; Injection: 5 mg/ml

STORAGE: Tablets should be stored between 2-30 C (36-86 F).

PRESCRIBED FOR: Labetalol is used alone or in combination with other drugs to reduce blood pressure.

DOSING: The recommended starting oral dose of labetalol is 100 mg twice daily and the dose can be increased by 100 mg twice daily every 2-3 days based on the response of the blood pressure. Usual maintenance doses are 200-400 mg twice daily. Patients with severely high blood pressure may require 1.2 to 2.4 g daily.

Side effects may be less if labetalol is given in three daily doses rather than two. Stopping or changing the dose of the drug should be directed by a physician because serious side effects may occur. The initial intravenous dose of labetalol is 20 mg injected over 2 minutes. Additional injections of 40 or 80 mg may be administered every 10 minutes as needed up to a total dose of 300 mg. Labetalol also may be administered by intravenous infusion at 1-2 mg/minute.




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