Klonopin (clonazepam) vs. Xanax (alprazolam)

What are the side effects of Klonopin (clonazepam) vs. Xanax (alprazolam)?

Klonopin (clonazepam) side effects

The most common side effects associated with Klonopin (clonazepam) are sedation, which is reported in approximately half of patients. Dizziness is reported in one-third of patients.

Other common side effects include:

• A feeling of depression
• Loss of orientation
• Headache
• Weakness
• Unsteadiness
• Sleep disturbance
• Lack of inhibition
• Fatigue
• Amnesia
• Confusion
• Changes in sexual desire
• Rash
• Irritability

Other serious side effects of Klonopin include:

• Respiratory depression
• Fainting
• Enlarged liver
• Withdrawal symptoms (if stopped suddenly)
• Increased heart rate
• Low blood pressure
• Blood disorders

Other serious adverse reactions:

• Antiepileptic medications have been associated with an increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need for the antiepileptic drug. Patients who begin antiepileptic therapy should be closely observed for clinical worsening, suicidal thoughts or unusual changes in behavior.

Xanax (alprazolam) side effects

The most common side effects of Xanax taken at lower doses are:

• Drowsiness
• Fatigue

Other side effects include:

• Fatigue
• Memory problems
• Speech problems
• Constipation
• Changes in weight
• Addiction (dependency)

What are the withdrawal symptoms of Klonopin (clonazepam) vs. Xanax (alprazolam)?

Klonopin (clonazepam) withdrawal symptoms

• Like all benzodiazepines, Klonopin can cause physical dependence.
• Suddenly stopping therapy after a few months of daily therapy may be associated with a feeling of loss of self-worth, agitation, and insomnia.
• If Klonopin is taken continuously for longer than a few months, stopping therapy suddenly may produce:
  • Seizures
  • Tremors
  • Muscle cramping
  • Vomiting
  • Sweating
• Therefore, discontinuation usually is accomplished by reducing the dose gradually.

Xanax (alprazolam) withdrawal symptoms

Addiction is more likely to occur at high doses given over prolonged periods of time. Abrupt discontinuation of Xanax after prolonged use can lead to symptoms of withdrawal such as:

• Insomnia
• Headaches
• Nausea,
• Vomiting
• Lightheadedness
• Sweating
• Anxiety
• Fatigue

Seizures can occur in more severe cases of withdrawal. Consequently, patients on Xanax for extended periods of time should slowly taper the medication under a doctor's supervision rather than abruptly stopping the medication.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.