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November 25, 2009
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Klippel-Trenaunay-Weber Syndrome (cont.)

How is intelligence affected?

Intelligence is usually not impaired in Klippel-Trènaunay-Weber. However, when there are hemangiomas on the face (facial hemangiomatosis), there may also be hemangiomas in the brain which can cause seizures (convulsions) or mental retardation. Fortunately, such problems are rare in Klippel-Trènaunay-Weber.

What is the basic defect in Klippel-Trènaunay-Weber syndrome?

It is not completely known, but some researches believe part of the defect is related to the control of angiogenic cells (precursors of blood vessels). Others believe it is caused by some injury to the developing embryo within the womb, resulting in venous compression and resultant abnormal venous pressures, causing varicosities and limb enlargement. In other words, we don't currently know the precise events that lead to the development of Klippel-Trènaunay-Weber.

What causes Klippel-Trènaunay-Weber syndrome?

Most cases of Klippel-Trènaunay-Weber are sporadic. They occur without warning, with no prior case in the family; however recently there have been some cases that run in families.

What is the prognosis (outlook) with Klippel-Trènaunay-Weber syndrome?

Most persons with Klippel-Trènaunay-Weber have an enlarged leg and they do relatively well without any significant treatment. It can be helpful to wear compression stockings to prevent venous pooling in the affected extremity (varicose vein management). However, some Klippel-Trènaunay-Weber patients do have considerable pain. Skin ulcers, infections and other skin problems can occur, but usually the treatment is conservative. Surgery is almost never needed.



Next: Why is it called Klippel-Trènaunay-Weber syndrome? »

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