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In this Article

• What is Klinefelter syndrome?
• What are the symptoms of the XXY condition?
• Physical development
• Language development
• Social development
• What are the treatments for the XXY condition?
• Patient Comments: Klinefelter Syndrome - Symptoms
• Patient Comments: Klinefelter Syndrome - Treatments
• Klinefelter Syndrome Index

As boys, between 25 percent and 85 percent of XXY males have some kind of language problem, such as learning to talk late, trouble using language to express thoughts and needs, problems reading, and trouble processing what they hear.

As adults, XXY males may have a harder time doing work that involves reading and writing, but most hold jobs and have successful careers.

As babies, XXY males tend to be quiet and undemanding. As they get older, they are usually quieter, less self-confident, less active, and more helpful and obedient than other boys.

As teens, XXY males tend to be quiet and shy. They may struggle in school and sports, meaning they may have more trouble "fitting in" with other kids.

However, as adults, XXY males live lives similar to men without the condition; they have friends, families, and normal social relationships.

The XXY chromosome pattern can not be changed. But, there are a variety of ways to treat the symptoms of the XXY condition.

• Educational treatments - As children, many XXY males qualify for special services to help them in school. Teachers can also help by using certain methods in the classroom, such as breaking bigger tasks into small steps.
  
  
• Therapeutic options - A variety of therapists, such as physical, speech, occupational, behavioral, mental health, and family therapists, can often help reduce or eliminate some of the symptoms of the XXY condition, such as poor muscle tone, speech or language problems, or low self-confidence.
  
  
• Medical treatments - Testosterone replacement therapy (TRT) can greatly help XXY males get their testosterone levels into normal range. Having a more normal testosterone level can help develop bigger muscles, deepen the voice, and grow facial and body hair. TRT often starts when a boy reaches puberty. Some XXY males can also benefit from fertility treatment to help them father children.

One of the most important factors for all types of treatment is starting it as early in life as possible.

SOURCE: National Institutes of Child Health and Human Development, National Institutes of Health