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- Bacterial Infections 101 Slideshow
- Natural Cold & Flu Remedies Slideshow
- Patient Comments: Adenovirus 14 - Signs and Symptoms
- Adenovirus 14 (Ad14) facts
- What is the killer cold virus?
- What are symptoms and signs of an Adenovirus 14 infection?
- What causes an infection with Adenovirus 14 (Ad14)?
- How is an Adenovirus 14 infection diagnosed?
- What is the treatment for an Adenovirus 14 (Ad14) infection?
- What are complications of an Adenovirus 14 infection?
- What is the prognosis for an Adenovirus 14 (Ad14) infection?
- Can an Adenovirus 14 infection be prevented?
- Where can people get more information about the killer cold virus (Adenovirus 14)?
What causes an infection with Adenovirus 14 (Ad14)?
Usually, an individual becomes infected with Ad14 through person-to-person exposure via droplets containing Ad14 expelled by an infected person who coughs or sneezes. When these droplets reach the eyes, nose, or mouth, the Ad14 virus can attach and infect cells. These infected sites allow the virus to proliferate in some patients, and the virus then may go on to infect other organ systems, especially the lungs. Ad14 also can be passed through direct hand-to-hand contact if an infected patient has not washed their hands after coughing or sneezing. Adenoviruses can survive for days on objects like doorknobs, hand rails, and other objects. If a non-infected person touches the contaminated item, they can pick up the virus and then transfer it to a site (mouth, nose, eyes) where the virus can infect cells and proliferate.
How is an Adenovirus 14 infection diagnosed?
Diagnosis begins with a complete medical history and physical exam, especially noting if the patient has been associated with any group of people that has similar symptoms. Ad14 is one of several possible causative agents for an outbreak of respiratory problems in members of a group, like military recruits. To provide a definitive diagnosis of Ad14, blood, tissue, and/or exudates can be specifically cultured for the virus. Rising serum titers of antibodies toAd14, immunofluorescence tests for virus antigens in tissues, and a polymerase chain reaction (PCR) are also considered tests that provide a definitive diagnosis. However, in the vast majority of infected patients, such specific testing is not done and is not clinically necessary. It does not alter the management of the infected person. Electron microscopy shows the virus structure (Figure 1) but does not identify the strain. Supportive tests may include chest X-rays and blood tests and others that the physician deems appropriate.
For further information on Adenovirus structure, see http://www.ncbi.nlm.nih.gov/books/NBK8174/.