ketorolac tromethamine (Acular, Acular LS, Acuvail)

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GENERIC NAME: Ketorolac tromethamine

BRAND NAME: Acular, Acular LS, Acuvail

DRUG CLASS AND MECHANISM: Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, indomethacin, naproxen, and many others. Ketorolac blocks prostaglandin synthesis. Prostaglandins have many effects in the body including their role in pain and inflammation. In the eye prostaglandin is involved in inflammation, pain, and irritation due to allergies or mechanical injury. Ketorolac provides relief from pain and inflammation in the eyes. The FDA approved ketorolac eye drops in November 1992.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Ophthalmic Solution: 0.4%, 0.45%, 0.5%

STORAGE: Store Ketorolac eye drops between temperatures 5 C to 30 C (59 F to 86 F), and protect from light.

PRESCRIBED FOR: Ketorolac tromethamine eye drops are used for allergic conjunctivitis (pink eye) and for the treatment of post-operative inflammation, pain, burning, and stinging after eye procedures such as cataract surgery and corneal refractory surgery.

Allergic conjunctivitis: Adults and children 2 years and older: Instill 1 drop into affected eye(s) 4 times a day

Post-operative inflammation: Adults and children 2 years and older: Instill 1 drop into operative eye(s) 2 times a day starting 1 day before surgery and continue for 4 weeks when using Acuvail. For Acular, instill 1 drop into operative eye(s) 4 times a day starting 24 hours after procedure and continuing for 2 weeks.

Safe and effective use of Ketorolac is not established for children under 2 years of age.

DRUG INTERACTIONS: Ketorolac should not be used with other NSAID eye drops due to risks of increased bleeding and delayed healing.

Ketorolac should be used with caution with steroid-containing eye drops due to increased likelihood of infections.

Ketorolac should be used with caution in patients who bleed easily or patients receiving blood thinners.

PREGNANCY: There are no adequate studies done on Ketorolac to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether Ketorolac enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

SIDE EFFECTS: Side effects of Ketorolac are burning and stinging of eyes, corneal edema, inflammation and irritation, eye infection, dryness, visual disturbances, and headache.

REFERENCE: Ketorolac FDA Prescribing Information.


Medically Reviewed by a Doctor on 5/30/2014



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