- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is ketorolac-oral, and how does it work (mechanism of action)?
- Is ketorolac-oral available as a generic drug?
- Do I need a prescription for ketorolac-oral?
- What are the uses for ketorolac-oral?
- What are the side effects of ketorolac-oral?
- What is the dosage for ketorolac-oral?
- Which drugs or supplements interact with ketorolac-oral?
- Is ketorolac-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about ketorolac-oral?
What is ketorolac-oral, and how does it work (mechanism of action)?
- Ketorolac is a member of a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that are used for treating inflammation and pain. Other drugs in this class include ibuprofen (Motrin) and naproxen (Naprosyn, Aleve), but ketorolac is more effective than other NSAIDs in reducing pain from both inflammatory and non-inflammatory causes. Ketorolac reduces the production of prostaglandins, chemicals that cells of the immune system make that cause the redness, fever, and pain of inflammation and that also are believed to be important in the production of non-inflammatory pain. It does this by blocking the enzymes that cells use to make prostaglandins (cyclooxygenase 1 and 2). As a result, pain as well as inflammation and its signs and symptoms, redness, swelling, fever, and pain, are reduced.
- The FDA approved ketorolac in November 1989.
Is ketorolac-oral available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for ketorolac-oral?
What are the uses for ketorolac-oral?
- Ketorolac is used for short-term management (up to 5 days) of moderately severe acute pain that otherwise would require narcotics.
- It should not be used for minor or chronic painful conditions.
What are the side effects of ketorolac-oral?
Common side effects from ketorolac include:
- Ringing in the ears
- Abdominal pain
- Fluid retention
Rare side effects of ketorolac include:
- Abnormal thinking
- Serious allergic reactions
- Blurred vision
- Difficulty concentrating
- Taste abnormality
- Hemolytic-uremic syndrome
- High potassium blood levels
- Low sodium levels
Serious side effects of ketorolac include:
- Stomach ulcers
- Intestinal bleeding
- Reduced kidney function
- Liver failure
Other serious adverse events include:
- NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Ketorolac may cause ulcers and bleeding in the stomach and intestines, particularly with use for more than five days. Sometimes, stomach ulceration and intestinal bleeding can occur without any abdominal pain. Sometimes, the only signs or symptoms of bleeding may be:
- NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously.
- Liver failure has also been associated with ketorolac.
- People who are allergic to aspirin and other NSAIDs should not use ketorolac.
- Individuals with asthma or nasal polyps are more likely to experience allergic reactions to NSAIDs.
Quick GuideChronic Pain: Causes and Solutions
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