ketoprofen None (Note: previous brand names no longer available in the US include Orudis, Oruvail) (cont.)

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PRESCRIBED FOR: Ketoprofen is used for the treatment of inflammation and pain caused by rheumatoid arthritis and osteoarthritis. It also is used for menstrual cramps and mild to moderate pain of many causes. Extended release capsules are not used for acute pain because they do not begin working as quickly as the immediate release capsules.

DOSING: The usual starting dose of ketoprofen is 50 or 75 mg with immediate release capsules every 6 to 8 hours or 200 mg with extended release capsules once daily. The maximum dose is 300 mg daily of immediate release capsules or 200 mg daily of extended release capsules. Ketoprofen should be taken with food in order to avoid stomach upset.

DRUG INTERACTIONS: Ketoprofen may increase the blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys which may lead to lithium toxicity.

Ketoprofen may reduce the blood pressure lowering effects of blood pressure medications. This occurs because prostaglandins play a role in reducing blood pressure.

When NSAIDs are combined with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase because the elimination of methotrexate and aminoglycosides is reduced. This may lead to more methotrexate or aminoglycoside side effects.

Individuals taking blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid ketoprofen because ketoprofen also thins the blood, and excessive blood thinning may lead to bleeding.

Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking ketoprofen or other NSAIDs.

PREGNANCY: There are no adequate studies of ketoprofen in pregnant women. Therefore, ketoprofen is not recommended during pregnancy.

NURSING MOTHERS: It is not known whether ketoprofen is excreted in breast milk.

SIDE EFFECTS: The most common side effects from ketoprofen are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, retention of fluid and shortness of breath.

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