ketoprofen (Discontinued brands: Nexcede, Orudis, Oruvail, Actron)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is the dosage for ketoprofen?

  • The usual starting dose of ketoprofen is 50 or 75 mg with immediate release capsules every 6 to 8 hours or 200 mg with extended release capsules once daily.
  • The maximum dose is 300 mg daily of immediate release capsules or 200 mg daily of extended release capsules.
  • Ketoprofen should be taken with food in order to avoid stomach upset.
  • Menstrual cramps are treated with 25-50 mg every 6 to 8 hours using immediate release capsules.
  • Rheumatoid or osteoarthritis are treated with 75 mg three times daily or 50 mg four times daily using immediate release capsules or 200 mg daily of extended release capsules.

Which drugs or supplements interact with ketoprofen?

  • Ketoprofen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys which may lead to lithium toxicity.
  • Ketoprofen may reduce the blood pressure lowering effects of blood pressure medications. This occurs because prostaglandins play a role in reducing blood pressure.
  • When NSAIDs are combined with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase because their elimination is reduced. This may lead to more methotrexate or aminoglycoside side effects.
  • Individuals taking blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid ketoprofen because ketoprofen also thins the blood, and excessive blood thinning may lead to bleeding.
  • Combining NSAIDs such as ketoprofen with angiotensin receptor blockers (ARBs) (for example valsartan [Diovan], losartan [Cozaar], irbesartan [Avapro]) or angiotensin converting enzyme inhibitors (ACE inhibitors), (for example, enalapril [Vasotec], captopril [Capoten] in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
  • Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking ketoprofen or other NSAIDs.

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