ketoconazole (cont.)
Ketoconazole also may reduce the elimination of some "statins" [for example, simvastatin
(Zocor)] leading to
an increase in the blood levels of statins and increasing the risk of side
effects such as rhabdomyolysis (severe muscle injury).
PREGNANCY: Ketoconazole has not been adequately studied in
pregnant
women.
NURSING MOTHERS: A small amount of ketoconazole is secreted in breast milk.
Nursing mothers should probably avoid
breastfeeding while using ketoconazole.
SIDE EFFECTS: Ketoconazole is generally well tolerated. Ketoconazole
can cause rash, itching, nausea,
vomiting, abdominal pain, headache, dizziness,
fatigue, impotence, and blood count abnormalities. Rarely, ketoconazole has
serious allergic reactions (anaphylaxis). Also rarely, ketoconazole has been
associated with severe depression, hair loss, and tingling sensations. Liver
dysfunction has also been reported. Signs of liver problems include unusual
fatigue, loss of appetite, nausea and vomiting, yellowing of the skin
(jaundice), dark urine, and pale stools. Development of these symptoms while
taking ketoconazole should be reported to a physician.
Reference: FDA Prescribing Information
Last Editorial Review: 12/15/2008
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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