PRECAUTIONS: Tell your doctor your medical history especially: liver disease, history of alcohol use, digestion problems, any drug allergies. Do not consume alcoholic beverages while taking this drug. This medication should be used during pregnancy only when clearly needed. Discuss the risks and benefits with your doctor. Ketoconazole may be excreted into breast milk. The manufacturer of this drug recommends you do not breast-feed while using this drug. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: certain "statin" drugs (e.g., atorvastatin, lovastatin, simvastatin), alprazolam, midazolam, triazolam, nevirapine. If you are currently using any of these medications, tell your doctor or pharmacist before starting ketoconazole. Tell your doctor of all prescription and nonprescription drugs you may use, especially: drugs used for ulcers or heartburn (e.g., cimetidine or omeprazole-like drugs), antacids, certain antihistamines (terfenadine, astemizole), "blood thinners" (e.g., warfarin), phenytoin, rifamycins (e.g., rifampin, rifabutin), certain calcium channel blockers (dihydropyridines such as nifedipine, felodipine), sildenafil, cisapride, certain anticholinergic drugs (e.g., propantheline), indinavir. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.