- Take the Liver Disease Quiz
- A Visual Guide to Hepatitis Slideshow
- Take the Alcohol Quiz
- Patient Comments: Jaundice in Adults - Experience
- Patient Comments: Jaundice in Adults - Treatment
- Patient Comments: Jaundice in Adults - Complications
- Jaundice definition
- Jaundice in adults
- What causes jaundice in adults?
- Pre-hepatic causes
- Hepatic causes
- Post-hepatic causes
- What are the symptoms of jaundice in adults?
- What are the risk factors for jaundice in adults?
- How is jaundice in adults diagnosed?
- What is the treatment for jaundice in adults?
- What are the complications of jaundice in adults?
- Can jaundice in adults be prevented?
- What is the prognosis of jaundice in adults?
Jaundice caused during the pre-hepatic phase is due to the excessive destruction (hemolysis) of red blood cells from various conditions. This rapid increase in bilirubin levels in the bloodstream overwhelms the liver's capability to properly metabolize the bilirubin, and consequently the levels of unconjugated bilirubin increase. Conditions which can lead to an increase in the hemolysis of red blood cells include:
- Sickle cell disease,
- Hereditary spherocytosis,
- Glucose-6-phosphate dehydrogenase deficiency (G6PD),
- Drugs or other toxins, and
- Autoimmune disorders.
Jaundice caused during the hepatic phase can arise from abnormalities in the metabolism and/or excretion of bilirubin. This can lead to increase in both unconjugated and/or conjugated bilirubin levels. Conditions with a hepatic cause of jaundice include:
- Acute or chronic hepatitis (commonly viral [Hepatitis A, B, C, D, E] or alcohol related),
- Cirrhosis (caused by various conditions),
- Drugs or other toxins,
- Crigler-Najjar syndrome,
- Autoimmune disorders,
- Gilbert's syndrome, and
- Liver cancer.