itraconazole, Sporanox (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin (Rifadin), rifabutin (Mycobutin) and isoniazid reduce the blood concentration of oral itraconazole, probably by increasing the elimination of itraconazole by the liver. This may reduce the effectiveness of itraconazole. Itraconazole tablets require acid from the stomach to dissolve. Therefore, itraconazole should be administered at least two hours before taking antacids or other acid reducing medications such as cimetidine (Tagamet), ranitidine (Zantac) or omeprazole (Prilosec).

PREGNANCY: Itraconazole has not been adequately studied in pregnant women. Cases of congenital abnormalities have been reported. Itraconazole should not be used to treat nail fungal infections (onychomycosis) in pregnant patients. Women of child bearing age undergoing treatment for fungal infections of the nails must use adequate contraception measures while receiving itraconazole and for two months after treatment.

NURSING MOTHERS: Itraconazole is excreted in human milk. Therefore, it should not be administered to nursing women or, alternatively, breastfeeding should be discontinued.

SIDE EFFECTS: The most common side effects of itraconazole include nausea, vomiting, diarrhea, rash, edema, fatigue, dizziness. High blood pressure (hypertension) and increased blood triglycerides may also occur. Less common but more serious side effects include hepatitis and congestive heart failure.

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