Disclaimer

itraconazole solution - oral, Sporanox (cont.)

PRECAUTIONS: Before taking itraconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals (e.g., ketoconazole); or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (including history of liver disease with other drugs), kidney disease, heart disease (e.g., coronary artery disease, heart valve disease, congestive heart failure), severe lung disease (e.g., chronic obstructive pulmonary disease-COPD), high blood pressure, decreased or no stomach acid (e.g., achlorhydria).This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages since they can increase the effects of dizziness and also increase the risk of serious liver problems.Older adults may be at greater risk for hearing loss while using this drug.During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.Itraconazole passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: See also Warning and How to Use sections.Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.This drug should not be used with the following medications because very serious interactions may occur: alfuzosin, certain benzodiazepines (e.g., oral midazolam, triazolam, alprazolam, estazolam), certain "statin" drugs (e.g., lovastatin, simvastatin), conivaptan, eletriptan, eplerenone, ergot alkaloids (e.g., ergotamine, dihydroergotamine), ivabradine, nisoldipine, ranolazine, vardenafil.If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting itraconazole.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: amiodarone, calcium channel blockers (e.g., verapamil, nifedipine), drugs affecting liver enzymes that remove itraconazole from your body (such as macrolide antibiotics including erythromycin; cimetidine; isoniazid; rifamycins including rifabutin; efavirenz; nevirapine; certain anti-seizure medicines including carbamazepine; phenytoin).This drug can slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include certain antiarrhythmic medications (e.g., disopyramide, digoxin), certain chemotherapy drugs (e.g., busulfan, docetaxel, vinblastine, sunitinib, lapatinib, dasatinib), certain benzodiazepines (e.g., diazepam, injectable midazolam), certain immunosuppressants (e.g., tacrolimus, cyclosporine, sirolimus), certain "statin" drugs (e.g., atorvastatin), HIV protease inhibitors (e.g., indinavir, ritonavir, saquinavir), certain anti-diabetic drugs (e.g., oral hypoglycemics such as glyburide), halofantrine, alfentanil, fentanyl, solifenacin, buspirone, repaglinide, certain glucocorticosteroids (e.g., dexamethasone, budesonide), certain drugs for male erectile problems (e.g., sildenafil, tadalafil), trimetrexate, aripiprazole, trazodone, tolterodine, "blood thinners" (e.g., warfarin), and cilostazol.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



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