Itch (Itching or Pruritus)

  • Medical Author:
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

  • Medical Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Quick GuideRosacea, Acne, Shingles: Common Adult Skin Diseases

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What are oral medications that treat itch?

Traditionally, antihistamines are used to treat itch. Examples include diphenhydramine (Benadryl), hydroxyzine (Atarax), and chlorpheniramine (Chlor-Trimeton and others). These medicines can induce drowsiness in many people and must be used with care before driving a car or operating heavy machinery. Although antihistamines may help relieve itchy skin, they seem to do so mainly by helping people fall asleep and avoid scratching at night. If falling or staying asleep is not your main problem, you may want to try one of the nonsedating antihistamines. Loratadine (Claritin) and fexofenadine (Allegra and others) are examples of newer second-generation antihistamines that are available without a prescription. The second-generation antihistamines do not have the sedating effects of the older first-generation antihistamines but they are not very effective in quelling the itch.

Reviewed on 5/11/2017
References
REFERENCES:

Butler, David F. "Pruritus and Systemic Disease." Medscape.com. Mar. 8, 2016. <http://emedicine.medscape.com/article/1098029-overview>.

Mann, Julianne. "Brachioradial Pruritus." Medscape.com. Aug. 12, 2016. <http://emedicine.medscape.com/article/1355312-overview>.

United States. Centers for Disease Control and Prevention. "Cercarial Dermatitis." Jan. 10, 2012.<http://www.cdc.gov/parasites/swimmersitch/faqs.html>.

United States. National Cancer Institute. "Pruritus." June 15, 2016. <http://www.cancer.gov/cancertopics/pdq/supportivecare/pruritus/Patient/page1>.

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