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- What is isosorbide mononitrate, and how does it work (mechanism of action)?
- What brand names are available for isosorbide mononitrate?
- Is isosorbide mononitrate available as a generic drug?
- Do I need a prescription for isosorbide mononitrate?
- What are the side effects of isosorbide mononitrate?
- What is the dosage for isosorbide mononitrate?
- Which drugs or supplements interact with isosorbide mononitrate?
- Is isosorbide mononitrate safe to take if I'm pregnant or breastfeeding?
- What else should I know about isosorbide mononitrate?
What is the dosage for isosorbide mononitrate?
The recommended starting dose of isosorbide mononitrate is 5 to 10 mg of immediate release tablets twice daily. The dose can be increased to 10 mg twice daily after 2 to 3 days. The target does is 20 mg twice daily. The two doses should be administered 7 hours apart in order to avoid tolerance (decreased effect after several doses). The dose for extended release tablets is 30-240 mg once daily.
Which drugs or supplements interact with isosorbide mononitrate?
Sildenafil (Viagra), tadalafil (Cialis), avanafil (Stendra),and vardenafil (Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. Therefore, patients taking isosorbide mononitrate should not receive sildenafil, tadalafil, avanafil or vardenafil.
Severe reductions in blood pressure, especially when changing posture (orthostatic hypotension), may occur when isosorbide mononitrate is combined with calcium channel blockers [for example, diltiazem (Cardizem, Dilacor, Tiazac and several others), verapamil (Calan, Verelan, Verelan PM, Isoptin, Isoptin SR, Covera-HS)], which also reduce blood pressure.
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