isosorbide mononitrate, Imdur, Ismo, Monoket (cont.)

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Angina pectoris (angina) or "heart pain" is due to an inadequate flow of blood (and oxygen) to the muscle of the heart. Nitrates, including isosorbide mononitrate, correct the imbalance between the flow of blood and oxygen to the heart and the work that the heart must do by dilating the arteries and veins in the body. Dilation of the veins reduces the amount of blood that returns to the heart that must be pumped. Dilation of the arteries lowers the pressure in the arteries against which the heart must pump. As a consequence of both effects, the heart works less and requires less blood and oxygen.



PREPARATIONS: Tablets (immediate release): 10, 20 mg. Tablets (extended release): 30, 60, 120 mg.

STORAGE: Isosorbide mononitrate should be stored at room temperature, 15 C - 30 C (59 F - 86 F) in a tight, moisture- proof container.

PRESCRIBED FOR: Isosorbide mononitrate is used for the treatment and prevention of angina. It can be used to decrease the frequency and severity of anginal (chest pain) episodes and to reduce the need for sublingual (under the tongue) nitroglycerin.

DOSING: The recommended starting dose of isosorbide mononitrate is 5 to 10 mg of immediate release tablets twice daily. The dose can be increased to 10 mg twice daily after 2 to 3 days. The target does is 20 mg twice daily. The two doses should be administered 7 hours apart in order to avoid tolerance (decreased effect after several doses). The dose for extended release tablets is 30-240 mg once daily.

DRUG INTERACTIONS: Sildenafil (Viagra), tadalafil (Cialis), avanafil (Stendra),and vardenafil (Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. Therefore, patients taking isosorbide mononitrate should not receive sildenafil, tadalafil, avanafil or vardenafil.

Medically Reviewed by a Doctor on 10/30/2014

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