isosorbide mononitrate, Imdur, Ismo, Monoket (cont.)

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PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets (immediate release): 10, 20 mg. Tablets (extended release): 30, 60, 120 mg.

STORAGE: Isosorbide mononitrate should be stored at room temperature, 15 C - 30 C (59 F - 86 F) in a tight, moisture- proof container.

PRESCRIBED FOR: Isosorbide mononitrate is used for the treatment and prevention of angina. It can be used to decrease the frequency and severity of anginal (chest pain) episodes and to reduce the need for sublingual (under the tongue) nitroglycerin.

DOSING: The recommended starting dose of isosorbide mononitrate is 5 to 10 mg of immediate release tablets twice daily. The dose can be increased to 10 mg twice daily after 2 to 3 days. The target does is 20 mg twice daily. The two doses should be administered 7 hours apart in order to avoid tolerance (decreased effect after several doses). The dose for extended release tablets is 30-240 mg once daily.

DRUG INTERACTIONS: Sildenafil (Viagra), tadalafil (Cialis), avanafil (Stendra),and vardenafil (Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. Therefore, patients taking isosorbide mononitrate should not receive sildenafil, tadalafil, avanafil or vardenafil.

Severe reductions in blood pressure, especially when changing posture (orthostatic hypotension), may occur when isosorbide mononitrate is combined with calcium channel blockers [for example, diltiazem (Cardizem, Dilacor, Tiazac and several others), verapamil (Calan, Verelan, Verelan PM, Isoptin, Isoptin SR, Covera-HS)], which also reduce blood pressure.

PREGNANCY: There are no adequate studies of isosorbide mononitrate in pregnant women..

NURSING MOTHERS: It is not known if isosorbide mononitrate is excreted in human breast-milk

Medically Reviewed by a Doctor on 10/30/2014


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