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- What is isosorbide mononitrate, and how does it work (mechanism of action)?
- What brand names are available for isosorbide mononitrate?
- Is isosorbide mononitrate available as a generic drug?
- Do I need a prescription for isosorbide mononitrate?
- What are the side effects of isosorbide mononitrate?
- What is the dosage for isosorbide mononitrate?
- Which drugs or supplements interact with isosorbide mononitrate?
- Is isosorbide mononitrate safe to take if I'm pregnant or breastfeeding?
- What else should I know about isosorbide mononitrate?
What is isosorbide mononitrate, and how does it work (mechanism of action)?
Isosorbide mononitrate is in the class of drugs called nitrates that are used for treating and preventing angina. Other nitrates include nitroglycerin (Nitrostat, NitroQuick, Nitrolingual, Nitro-Dur and others) and isosorbide dinitrate (Isordil Titradose, Dilatrate-SR, Isochron). Nitrates are vasodilators (dilators of blood vessels). Blood returning from the body in the veins must be pumped by the heart through the lungs and into the body's arteries against the high pressure in the arteries. In order to accomplish this work, the heart's muscle must produce and use energy ("fuel") which requires oxygen brought to the heart by the blood. The FDA approved isosorbide mononitrate in December 1991.
Angina pectoris (angina) or "heart pain" is due to an inadequate flow of blood (and oxygen) to the muscle of the heart. Nitrates, including isosorbide mononitrate, correct the imbalance between the flow of blood and oxygen to the heart and the work that the heart must do by dilating the arteries and veins in the body. Dilation of the veins reduces the amount of blood that returns to the heart that must be pumped. Dilation of the arteries lowers the pressure in the arteries against which the heart must pump. As a consequence of both effects, the heart works less and requires less blood and oxygen.
What brand names are available for isosorbide mononitrate?
Imdur (discontinued brand), Ismo (discontinued brand), Monoket
Is isosorbide mononitrate available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for isosorbide mononitrate?
What are the side effects of isosorbide mononitrate?
Headaches are the most common side effect of isosorbide mononitrate and usually are dose related (increase with higher doses). Flushing may occur because isosorbide mononitrate dilates (enlarges) blood vessels. Isosorbide mononitrate may cause a severe drop in blood pressure when rising from a sitting position, causing:
To reduce the risk of low blood pressure, patients should rise slowly from a sitting position.
Quick GuideHeart Disease: Symptoms, Signs, and Causes
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