isosorbide dinitrate (Isordil Titradose, Dilatrate-SR, Isochron) (cont.)

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Nitrates are vasodilators (dilators of blood vessels). Blood returning from the body in the veins must be pumped by the heart through the lungs and into the body's arteries against the high pressure in the arteries. In order to accomplish this work, the heart's muscle must produce and use energy ("fuel"), and this requires oxygen. Angina pectoris (angina) or "heart pain" is due to an inadequate flow of blood (and oxygen) to the muscle of the heart. Nitrates, including isosorbide dinitrate, improve the flow of blood and oxygen to the heart and reduce the work that the heart must do by dilating (expanding) the arteries and veins in the body. Dilation of the veins reduces the amount of blood that returns to the heart that must be pumped. Dilation of the arteries lowers the pressure in the arteries against which the heart must pump. As a consequence of both effects, the heart works less and requires less blood and oxygen. In addition, nitrates dilate the arteries that supply the heart with blood so that the heart receives more blood and oxygen. The FDA approved isosorbide dinitrate in January 1968.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets (sublingual): 2.5 and 5 mg. Tablets (immediate release): 5, 10, 20, 30, and 40 mg. Tablets (extended release): 40 mg. Capsules (sustained release): 40 mg

STORAGE: Isosorbide dinitrate should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

PRESCRIBED FOR: Isosorbide dinitrate is used for the treatment and prevention of angina caused by coronary artery disease. Only sublingual tablets are used for immediate treatment of angina because the onset of action of other forms of isosorbide dinitrate is not fast enough. Isosorbide dinitrate sometimes is used for treating congestive heart failure.

DOSING: Isosorbide dinitrate tablets can be taken with or without food. The sublingual tablets should be dissolved under the tongue and should not be crushed or chewed. Tolerance (reduced effect after several doses) may develop, so a drug free period of at least 14 hours is recommended. The recommended doses of isosorbide dinitrate are:

  • Tablets: 5-40 mg 2 or 3 times daily
  • Tablets: (sublingual): 2.5-5 mg 15 minutes before activities likely to cause chest pain. For treating chest pain, 2.5 to 5 mg is taken every 5 to 10 minutes.
  • Tablets: (extended-release) and capsules (sustained-release): 40-80 mg once or twice daily.
Medically Reviewed by a Doctor on 10/29/2014


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