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- What is isosorbide dinitrate, and how does it work (mechanism of action)?
- What brand names are available for isosorbide dinitrate?
- Is isosorbide dinitrate available as a generic drug?
- Do I need a prescription for isosorbide dinitrate?
- What are the side effects of isosorbide dinitrate?
- What is the dosage for isosorbide dinitrate?
- Which drugs or supplements interact with isosorbide dinitrate?
- Is isosorbide dinitrate safe to take if I'm pregnant or breastfeeding?
- What else should I know about isosorbide dinitrate?
What is the dosage for isosorbide dinitrate?
Isosorbide dinitrate tablets can be taken with or without food. The sublingual tablets should be dissolved under the tongue and should not be crushed or chewed. Tolerance (reduced effect after several doses) may develop, so a drug free period of at least 14 hours is recommended. The recommended doses of isosorbide dinitrate are:
- Tablets: 5-40 mg 2 or 3 times daily
- Tablets: (sublingual): 2.5-5 mg 15 minutes before activities likely to cause chest pain. For treating chest pain, 2.5 to 5 mg is taken every 5 to 10 minutes.
- Tablets: (extended-release) and capsules (sustained-release): 40-80 mg once or twice daily.
Which drugs or supplements interact with isosorbide dinitrate?
Sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) increase the blood pressure lowering effects of isosorbide dinitrate and may cause excessive blood pressure reduction. Patients taking isosorbide dinitrate should not take sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra). Severe blood pressure reduction, especially when changing posture, may occur when isosorbide dinitrate is combined with calcium channel blockers, for example, diltiazem (Cardizem, Tiazac, etc.) and verapamil (Calan, Verelan, etc.) which also reduce blood pressure.
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