Combining irbesartan or other ARBs with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. There have been reports that aspirin and other NSAIDs such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ARBs.
PREGNANCY: All ARBs should not be used during pregnancy. When used in the second or third trimester of pregnancy, irbesartan and similar drugs may cause injury and even death to the fetus. Irbesartan should not be used during pregnancy. When pregnancy is detected, irbesartan should be stopped as soon as possible.
NURSING MOTHERS: It is not known whether irbesartan is secreted into human milk. Irbesartan is secreted into the milk of rats.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Use the pill identifier tool on RxList.