irbesartan, Avapro (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
SIDE EFFECTS: The most common side effects of irbesartan are:
Other important side effects patients may experience include:
Rhabdomyolysis (inflammation and destruction of muscle) and angioedema (swelling of soft tissues including those of the throat and larynx) are rare but serious side effects of irbesartan.
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 75 mg, 150 mg and 300 mg.
STORAGE: Tablets should be stored at room temperature, 15 C -30 C (59 F - 86 F).
DOSING: The recommended dose of irbesartan for treating hypertension is 75 to 300 mg once daily. Most hypertensive patients are started on 150 mg daily. Diabetic nephropathy is treated with 300 mg daily.
DRUG INTERACTIONS: Combining irbesartan with potassium-sparing diuretics (for example., spironolactone [Aldactone], triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to hyperkalemia (elevated potassium in the blood) and toxicity from potassium.
Combining irbesartan or other ARBs with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. There have been reports that aspirin and other NSAIDs such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ARBs.
Medically Reviewed by a Doctor on 12/31/2014
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