insulin glargine (Lantus) (cont.)

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DOSING:

Type 1 diabetes: For patients 6 years of age and older, patients' total daily insulin requirement must be calculated individually. In the beginning, insulin glargine should be one-third of the requirement, given subcutaneously once daily. The maintenance dose is determined based on individual response, given once daily. Insulin glargine must be used in combination with rapid or short acting insulin.

Type 2 diabetes: Start with 10 units of insulin glargine subcutaneously once daily at the same time every day. The maintenance dose is determined based on individual response.

Safe and effective use of insulin glargine is not established for children with type 2 diabetes nor in patients younger than 6 years of age with type 1 diabetes.

DRUG INTERACTIONS: There are many drugs that do not directly interfere with insulin glargine, but they may affect glucose breakdown in the body. This necessitates adjustments of insulin glargine doses.

Pramlintide (Symlin), disopyramide (Norpace), fenofibrate (Tricor), fluoxetine (Prozac), and aspirin can increase blood-sugar-lowering effect of insulin glargine.

Other drugs that can decrease the blood-sugar-lowering effect of insulin glargine are:

PREGNANCY: Safe and effective use of insulin glargine is not established for pregnant females.

NURSING MOTHERS: It is not known whether insulin glargine enters breast milk; therefore, it should be used with caution in females who are breastfeeding.

REFERENCE: FDA Prescribing Information.


Medically Reviewed by a Doctor on 12/23/2014


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