SIDE EFFECTS: Injection site reactions (e.g., pain, redness, irritation) may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these serious side effects of low blood sugar (hypoglycemia) occur: fainting, cold sweats, shaking/tremor, unusually fast heartbeat, headache, slurred speech, seizures. Tell your doctor immediately if any of these serious side effects of high blood sugar (hyperglycemia) occurs: unusual drowsiness, confusion, rapid breathing, fruity breath odor, increased urination, unusual thirst. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of: kidney problems, liver problems, nerve disease (e.g., diabetic neuropathy), thyroid problems, any allergies (especially to other insulin products). Fever, serious infection or injury, emotional stress, or major surgery may increase your blood sugar level temporarily which may make this medication less effective. Consult your doctor for details and a treatment plan. Caution is advised when using this drug in the elderly because they may be more sensitive to its effect on blood sugar. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially: other insulin products (e.g., Regular, NPH), oral diabetes medicine (e.g., glyburide, pioglitazone), ACE inhibitors (e.g., enalapril, lisinopril), beta-blockers (e.g., metoprolol, propranolol), disopyramide, fibrates (e.g., clofibrate, gemfibrozil), fluoxetine, MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine), propoxyphene, salicylates (e.g., aspirin), octreotide, sulfa antibiotics (e.g., sulfamethoxazole), corticosteroids (e.g., prednisone), danazol, diuretics, sympathomimetic drugs (e.g., albuterol, epinephrine), isoniazid, certain psychiatric medicine (e.g., phenothiazines such as chlorpromazine), somatropin, thyroid medicine, estrogens and progestins (including birth control pills), clonidine, lithium, pentamidine, guanethidine, reserpine. Drinking alcohol may affect your blood sugar level. Limit alcoholic beverages. Do not start or stop any medicine without doctor or pharmacist approval.