insulin glargine (Lantus) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Long term use of insulin glargine can lead to thickening of fat tissues at the injection site.

Severe allergic reactions are:

  • Swelling under the skin
  • Very low blood pressure
  • Bronchospasm (tightening of chest that leads to difficulty breathing)

Individuals should contact a healthcare professional if they experience any of the above reactions.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Insulin glargine is available as 100 units/ml. Insulin glargine is supplied in 10 ml vials, 3 ml SoloStar injectable pens, and a 3 ml cartridge system. Insulin glargine is given only by subcutaneous injection.

STORAGE:

  • Unopened vials, SoloStar pens, and cartridge systems should be refrigerated between 2 C and 8 C (36 F and 46 F).
  • Unopened vials, SoloStar pens, and cartridge systems, if refrigerated, are good until the expiration dates.
  • Unopened vials, SoloStar pens, and cartridge systems, stored at room temperature, are good for 28 days.
  • Opened vials and cartridge systems can be refrigerated or stored at room temperature below 30 C (86 F).
  • Cartridge systems inserted into the insulin delivery device and SoloStar pens should be stored only at room temperature below 30 C (86 F).
  • Opened vials, SoloStar pens, and cartridge systems are good for 28 days.

DOSING:

Type 1 diabetes: For patients 6 years of age and older, patients' total daily insulin requirement must be calculated individually. In the beginning, insulin glargine should be one-third of the requirement, given subcutaneously once daily. The maintenance dose is determined based on individual response, given once daily. Insulin glargine must be used in combination with rapid or short acting insulin.

Type 2 diabetes: Start with 10 units of insulin glargine subcutaneously once daily at the same time every day. The maintenance dose is determined based on individual response.

Safe and effective use of insulin glargine is not established for children with type 2 diabetes nor in patients younger than 6 years of age with type 1 diabetes.

DRUG INTERACTIONS: There are many drugs that do not directly interfere with insulin glargine, but they may affect glucose breakdown in the body. This necessitates adjustments of insulin glargine doses.

Pramlintide (Symlin), disopyramide (Norpace), fenofibrate (Tricor), fluoxetine (Prozac), and aspirin can increase blood-sugar-lowering effect of insulin glargine.

Medically Reviewed by a Doctor on 12/23/2014


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