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- What is infliximab, and how does it work (mechanism of action)?
- What brand names are available for infliximab?
- Is infliximab available as a generic drug?
- Do I need a prescription for infliximab?
- What are the uses for infliximab?
- What are the side effects of infliximab?
- What is the dosage for infliximab?
- Which drugs or supplements interact with infliximab?
- Is infliximab safe to take if I'm pregnant or breastfeeding?
- What else should I know about infliximab?
What is the dosage for infliximab?
Infliximab is administered intravenously. The recommended dose is a 5 mg/kg infusion at 0, 2, and 6 weeks and then 5 mg/kg every 8 weeks for moderate to severe active Crohn's disease or fistulizing Crohn's disease in adult or pediatric patients. Adults who initially responded then lost response may be treated with 10 mg/kg.
The recommended dose for the treatment of moderately to severely active rheumatoid arthritis is 3 mg/kg at 0, 2, and 6 weeks followed by 3 mg/kg every 8 weeks. Infliximab should be combined with methotrexate. If response is incomplete, up to 10 mg/kg or treating every 4 weeks may be tried.
Ankylosing spondylitis is treated with a 5 mg/kg infusion at 0, 2, and 6 weeks then 5 mg/kg every 6 weeks.
Which drugs or supplements interact with infliximab?
Because infliximab may reduce the response of the immune system, it should not be administered with vaccines containing live bacteria or viruses. Combining infliximab with anakinra (Kineret), abatacept (Orencia) or tocilizumab (Actemra), drugs that also reduce the response of the immune system, may increase the risk of serious infections.
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