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- What is indomethacin, and how does it work (mechanism of action)?
- What brand names are available for indomethacin?
- Is indomethacin available as a generic drug?
- Do I need a prescription for indomethacin?
- What are the side effects of indomethacin?
- What is the dosage for indomethacin?
- Which drugs or supplements interact with indomethacin?
- Is indomethacin safe to take if I'm pregnant or breastfeeding?
- What else should I know about indomethacin?
What is the dosage for indomethacin?
- The recommended adult dose of regular release indomethacin for treating inflammation or rheumatoid disorders is 50-200 mg per day split into 2-3 doses.
- The dose for extended release indomethacin is 75-150 mg divided into two daily doses.
- Bursitis or tendonitis are treated with a total dose of 75-150 mg daily of regular release indomethacin divided into 3 or 4 doses or 75-150 mg daily of extended release divided into two doses.
- Acute gouty arthritis is treated with 50 mg every 8 hours for 3 to 5 days. I
- Indomethacin should be taken with food and 8-12 ounces of water in order to reduce abdominal discomfort.
Which drugs or supplements interact with indomethacin?
Cholestyramine (Questran) and colestipol (Colestid) may decrease the absorption of indomethacin by binding to indomethacin in the intestine and preventing absorption into the body. Indomethacin and other NSAIDs may decrease the elimination of lithium (Eskalith, Lithobid) by the kidneys and, therefore, increase the blood level of lithium, which could lead to lithium toxicity.
Indomethacin may interfere with the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
When indomethacin is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
If aspirin is taken with indomethacin there may be an increased risk for developing an ulcer.
Persons who have more than 3 alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking indomethacin or other NSAIDs.
Individuals taking oral blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid indomethacin because indomethacin also thins the blood, and excessive blood thinning may lead to bleeding.PREGNANCY Use during pregnancy has not been adequately studied. Indomethacin may have adverse effects on the fetus.
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