indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Indomethacin increases the negative effect of cyclosporine on kidney function and reduces the effect of furosemide (Lasix) and thiazide diuretics because of prostaglandin inhibition.
Individuals taking oral blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid indomethacin because indomethacin also thins the blood, and excessive blood thinning may lead to bleeding.PREGNANCY: Use during pregnancy has not been adequately studied. Indomethacin may have adverse effects on the fetus.
NURSING MOTHERS: Indomethacin is excreted in breast milk and therefore should be avoided by nursing mothers.
Indomethacin may cause or worsen stomach or intestinal bleeding or ulcers. It may lead to perforation of the intestine.
NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury.
Indomethacin may cause ulceration of the stomach or intestine, and the ulcers may bleed. Sometimes, ulceration and bleeding can occur without abdominal pain, and black tarry stools, weakness, and dizziness upon standing (orthostatic hypotension) may be the only signs of a ulceration.
NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously. Individuals who have nasal polyps or are allergic to aspirin or other NSAIDs should not use indomethacin because there is an increased risk of severe allergic reactions in these individuals.
Reference: FDA Prescribing Information
Last Editorial Review: 12/5/2013
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