Indole-3-Carbinol

What other names is Indole-3-carbinol known by?

3-Hydroxymethyl Indole, 3 Hydroxymethyl Indole, I3C, Indole 3 Carbinol, 3-(hydroxymethyl), 3-(hydroxyméthyl), 3 (hydroxymethyl) Indole, 3-Indolylcarbinol, 3 Indolylcarbinol, 3-Indolylmethanol, 3 Indolylmethanol, Indol-3-Carbinol, Indole, Indole 3 Carbinol, Indole-3-methanol, Indole-3-méthanol.

What is Indole-3-carbinol?

Indole-3-carbinol is a substance found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. It can also be produced in the laboratory.

Indole-3-carbinol is used for prevention of breast cancer, colon cancer, and other types of cancer. The National Institutes of Health (NIH) has reviewed indole-3-carbinol as a possible cancer preventive agent and is now sponsoring clinical research for breast cancer prevention.

Indole-3-carbinol is also used for fibromyalgia, tumors inside the voice box (laryngeal papillomatosis) caused by a virus, tumors inside the respiratory tract (respiratory papillomatosis) caused by a virus, abnormal cell growth in the cervix (cervical dysplasia), and systemic lupus erythematosus (SLE). Some people use indole-3-carbinol to balance hormone levels, "detoxify" the intestines and liver, and to support the immune system.

Possibly Effective for...

  • Abnormal development and growth of cells of the cervix (cervical dysplasia).

Insufficient Evidence to Rate Effectiveness for...

  • Respiratory papillomatosis. There is some evidence that long-term use of indole-3-carbinol might reduce tumor (papilloma) growth in patients with recurrent respiratory papillomatosis.
  • Laryngeal papillomatosis.
  • Prevention of breast cancer.
  • Colon cancer.
  • Fibromyalgia.
  • Systemic lupus erythematosus (SLE).
  • Hormone imbalances.
  • Other conditions.
More evidence is needed to rate the effectiveness of indole-3-carbinol for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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