Indole-3-Carbinol

How does Indole-3-carbinol work?

Researchers are interested in indole-3-carbinol for cancer prevention, particularly breast, cervical and endometrial, and colorectal cancer. Their reason is that diets with higher amounts of fruit and vegetable consumption are associated with a decreased risk of developing cancer. Researchers suspect indole-3-carbinol is one of several vegetable components that might protect against cancer.

Are there safety concerns?

Indole-3-carbinol is likely safe for most people when used in amounts typically found in the diet. It seems to be safe for most people when used in medicinal amounts under proper medical supervision. It can cause side effects such as skin rashes and small increases in liver enzymes.

In very high doses, indole-3-carbinol can cause balance problems, tremor, and nausea.

Special Precautions & Warnings:

Pregnancy and breast-feeding: If you are pregnant or breast-feeding, stick with indole-3-carbinol in amounts typically found in the diet. Not enough is known about the safety of using indole-3-carbinol in larger medicinal amounts.


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