indinavir capsule - oral, Crixivan (cont.)
PRECAUTIONS: Before taking indinavir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood fat levels (cholesterol/triglycerides), diabetes, hemophilia, kidney problems (including kidney stones), heart problems (coronary artery disease, heart attack), liver problems.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Children may be more sensitive to the side effects of this drug, especially effects on the kidney (such as kidney stones).During pregnancy, this medication should be used only when clearly needed. However, it is now normal to prescribe HIV medicines for pregnant women with HIV. This has been shown to decrease the risk of giving HIV to the baby. Indinavir may be part of that treatment. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. Because breast milk can transmit HIV, do not breast-feed.
DRUG INTERACTIONS: The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.Some products that may interact with this drug include: amiodarone, atazanavir, certain benzodiazepines (alprazolam, midazolam, triazolam), conivaptan, eletriptan, ergot alkaloids (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine), pimozide, ranolazine, rifampin, certain "statin" cholesterol drugs (lovastatin, simvastatin), St. John's wort.Other medications can affect the removal of indinavir from your body, which may affect how indinavir works. Examples include rifabutin, venlafaxine, certain anti-seizure drugs (carbamazepine, phenytoin, phenobarbital), certain azole fungal medications (ketoconazole, itraconazole), among others.Indinavir can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include cisapride, lurasidone, regorafenib, trazodone, certain calcium channel blockers (such as nifedipine, felodipine, nicardipine), certain drugs that weaken the immune system (cyclosporine, tacrolimus, sirolimus), drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, vardenafil), salmeterol, among others.This document does not contain all possible drug interactions. Keep a list of all the products you use. Share the list with your doctor and pharmacist to lessen your risk for serious medication problems.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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