indinavir, Crixivan (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DRUG INTERACTIONS: Indinavir interacts with many drugs. Some of the important interactions are mentioned below. Patients should consult their health care professional before combining any drugs with indinavir.
Triazolam (Halcion), midazolam (Versed), alprazolam (Xanax), pimozide, lovastatin (Mevacor), simvastatin (Zocor), ergot derivatives (for example, ergotamine, dihydroergotamine), and amiodarone (Cordarone) should not be combined with indinavir due to the risk of serious adverse effects resulting from indinavir increasing the blood levels of these drugs.
Indinavir increases blood concentrations of stavudine (Zerit), alfuzosin (Uroxatral), oral contraceptives, and clarithromycin (Claritin). Increased blood levels may result in more frequent side effects.
Indinavir decreases the blood concentration of didanosine (Videx) in the body and can thereby reduce the effectiveness of didanosine. Therefore, when didanosine and indinavir are both being used for treatment, their ingestion should be separated by one hour.
Indinavir also may inhibit the break-down of the cholesterol-lowering drugs lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor). This may increase the risk of muscle breakdown (rhabdomyolysis) that may be seen when these drugs accumulate in the body.
Ketoconazole (Nizoral), itraconazole (Sporanox), delavirdine (Rescriptor) and clarithromycin (Claritin) can increase blood levels of indinavir and result in more frequent or severe side effects from indinavir.
Medically Reviewed by a Doctor on 7/9/2015
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Back to Medications Index
- Allergic Skin Disorders
- Bacterial Skin Diseases
- Bites and Infestations
- Diseases of Pigment
- Fungal Skin Diseases
- Medical Anatomy and Illustrations
- Noncancerous, Precancerous & Cancerous Tumors
- Oral Health Conditions
- Papules, Scales, Plaques and Eruptions
- Scalp, Hair and Nails
- Sexually Transmitted Diseases (STDs)
- Vascular, Lymphatic and Systemic Conditions
- Viral Skin Diseases
- Additional Skin Conditions