indinavir, Crixivan (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PRESCRIBED FOR: Indinavir is used for the treatment of HIV infection in combination with other other agents.
SIDE EFFECTS: The most common side effects of indinavir are:
Other important side effects include:
Like other protease inhibitors, use of indinavir may be associated with:
Kidney stones may be prevented by adequate fluid intake. Adequate fluid intake can be achieved by consuming at least 48 ounces of fluid daily. Immune reconstitution syndrome which is an inflammatory response to infection may occur in patients treated with combination antiretroviral therapy.
GENERIC AVAILABLE: No
PREPARATIONS: Capsules: 100, 200, and 400 mg
STORAGE: Indinavir should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in the original container and kept away from moisture. The desiccant (drying agent) in the original bottle should not be discarded.
DOSING: The recommended dose for adults is 800 mg every eight hours. Food reduces the absorption of indinavir. Therefore, for optimal absorption, indinavir should be taken with water one hour before or two hours after a meal; however, it may administered with skim milk, juice, coffee, tea or with a light meal such as dry toast or corn flakes.
The dose of indinavir should be reduced to 600 mg every 8 hours when it is combined with delaviridine (Rescriptor), itraconazole (Sporanox), ketoconazole (Nizoral), or in patients with liver failure. The dose of indinavir should be increased to 1000 mg every 8 hours when it is combined with rifabutin (Mycobutin).
Medically Reviewed by a Doctor on 7/9/2015
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