indinavir, Crixivan (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: No
PREPARATIONS: Capsules: 100, 200, and 400 mg
STORAGE: Indinavir should be stored at room temperature,15 C to 30 C (59 F to 86 F), in the original container and kept away from moisture. The desiccant (drying agent) in the original bottle should not be discarded.
PRESCRIBED FOR: Indinavir is used for the treatment of HIV infection in combination with other other agents.
DOSING: The recommended dose for adults is 800 mg every eight hours. Food reduces the absorption of indinavir. Therefore, for optimal absorption, indinavir should be taken with water one hour before or two hours after a meal; however, it may administered with skim milk, juice, coffee, tea or with a light meal such as dry toast or corn flakes.
The dose of indinavir should be reduced to 600 mg every 8 hours when it is combined with delaviridine (Rescriptor), itraconazole (Sporanox), ketoconazole (Nizoral), or in patients with liver failure. The dose of indinavir should be increased to 1000 mg every 8 hours when it is combined with rifabutin (Mycobutin).
DRUG INTERACTIONS: Indinavir interacts with many drugs. Some of the important interactions are mentioned below. Patients should consult their health care professional before combining any drugs with indinavir.
Triazolam (Halcion), midazolam (Versed), alprazolam (Xanax), pimozide, lovastatin (Mevacor), simvastatin (Zocor), ergot derivatives (for example, ergotamine, dihydroergotamine), and amiodarone (Cordarone) should not be combined with indinavir due to the risk of serious adverse effects resulting from indinavir increasing the blood levels of these drugs.
Indinavir increases blood concentrations of stavudine (Zerit), alfuzosin (Uroxatral), oral contraceptives, and clarithromycin (Claritin). Increased blood levels may result in more frequent side effects.
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