indapamide, Lozol (Discontinued) (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DRUG INTERACTIONS: Like other diuretics, indapamide can cause hypokalemia (low potassium) and hypomagnesemia (low magnesium). These changes can increase the risk of digoxin (Lanoxin) toxicity, possibly resulting in fatal abnormal heart rhythms. Use of amiodarone (Cordarone) and indapamide also can lead to cardiac arrhythmias. The ability of the kidney to eliminate lithium (Lithobid, Eskalith) is decreased in patients receiving diuretics, including indapamide. The use of these two drugs together could result in lithium toxicity.
PREGNANCY: The use of indapamide in pregnancy has not been well studied. Physicians may elect to use it if its benefits are judged to outweigh its potential risks.
NURSING MOTHERS: The use of indapamide in nursing mothers has not been studied.
SIDE EFFECTS: Dehydration may occur during indapamide therapy. Hypokalemia (low blood potassium due to elimination of potassium in the urine) is one of the most common adverse effects, and it may cause abnormal cardiac rhythms. The most common symptom associated with hypokalemia is muscle weakness. Patients receiving indapamide may need potassium supplements to prevent hypokalemia. Hypomagnesemia (low blood magnesium) also may occur.
Other possible side effects include low blood pressure, excessive loss of sodium (particularly of concern in elderly patients), increased cholesterol (this effect tends to diminish with continued use), increased blood glucose, increased uric acid concentrations in the blood, dizziness, lightheadedness, headache, blurred vision, tingling of the extremities, nervousness, impotence, rash, photosensitivity (skin rashes due to sunlight), fatigue, irritability, and agitation.
Reference: FDA Prescribing Information
Last Editorial Review: 4/4/2012
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