NURSING MOTHERS: It is not known if imipramine is secreted in breast milk.

SIDE EFFECTS: The most commonly encountered side effects associated with imipramine include fast heart rate, blurred vision, urinary difficulty urinating, dry mouth, constipation, weight gain or loss, and low blood pressure when standing. Rash, hives, seizures, and hepatitis are rare side effects. Imipramine also can cause elevated pressure in the eyes of some patients with glaucoma. Overdose with imipramine can cause life-threatening abnormal heart rhythms or seizures.

Following prolonged therapy in high doses, abrupt discontinuation of TCAs, including imipramine, could lead to certain cholinergic symptoms such as nausea, vomiting, or diarrhea. Therefore, many experts recommend gradually reducing the dose of drug if the drug is to be discontinued.

Reference: FDA Prescribing Information

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