imipramine, Tofranil, Tofranil-PM (cont.)

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Medical and Pharmacy Editor:

Other important side effects include:

Imipramine also can cause elevated pressure in the eyes of some patients with glaucoma.

Following prolonged therapy with high doses, abrupt discontinuation of TCAs, including imipramine, could lead to withdrawal symptoms such as nausea, vomiting, diarrhea, or restlessness. Therefore, many experts recommend gradually reducing the dose of drug if the drug is to be discontinued.

Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of imipramine  or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thinking or behavior, and unusual changes in behavior.

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 10, 25 and 50 mg. Capsule: 75, 100, 125 and 150 mg.

STORAGE: Imipramine should be stored below 86 F (30 C) in a tight, light resistant container.

DOSING: The dose range for treating depression is 75 to 300 mg daily. It may be given as a single dose or in divided doses. The recommended dose for enuresis is 10 to 75 mg daily at bedtime.

DRUG INTERACTIONS: Other medications and drugs that slow the brain's processes, such as alcohol, barbiturates, benzodiazepines, for example, lorazepam (Ativan), diazepam (Valium), temazepam (Restoril), oxazepam (Serax), clonazepam (Klonopin), zolpidem (Ambien), and narcotics, may add to the effect of imipramine on the brain.

Medically Reviewed by a Doctor on 1/30/2015


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