imipramine, Tofranil, Tofranil-PM

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GENERIC NAME: imipramine

BRAND NAME: Tofranil, Tofranil-PM

DRUG CLASS AND MECHANISM: Imipramine is an antidepressant medication of the tricyclic class. Medications in this class are often referred to as tricyclic antidepressants or TCAs. Depression is defined as an all-pervasive sense of sadness and gloom. In patients with depression, abnormal levels of chemicals in the brain (called neurotransmitters) may be the cause of their depression. These neurotransmitters are chemicals that the nerves in the brain use to communicate with each other. Imipramine is believed to elevate mood by raising the levels of neurotransmitters in the brain. Imipramine was first synthesized in the late 1940s and was approved by the FDA for depression in 1959 and for enuresis in 1973. PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets: 10, 25 and 50 mg. Capsule: 75, 100, 125 and 150 mg.

STORAGE: Imipramine should be stored below 86 F (30 C) in a tight, light resistant container.

PRESCRIBED FOR: Imipramine is FDA approved for treating depression and enuresis (bedwetting). It is sometimes used off-label to treat chronic pain in combination with other pain medications.

DOSING: The dose range for treating depression is 75 to 300 mg daily. It may be given as a single dose or in divided doses. The recommended dose for enuresis is 10 to 75 mg daily at bedtime.




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