GENERIC NAME: imipramine
BRAND NAME: Tofranil, Tofranil-PM
DRUG CLASS AND MECHANISM: Imipramine is an antidepressant medication of the tricyclic class. Medications in this class are often referred to as tricyclic antidepressants or TCAs. Depression is defined as an all-pervasive sense of sadness and gloom. In patients with depression, abnormal levels of chemicals in the brain (called neurotransmitters) may be the cause of their depression. These neurotransmitters are chemicals that the nerves in the brain use to communicate with each other. Imipramine is believed to elevate mood by raising the levels of neurotransmitters in the brain. Imipramine was first synthesized in the late 1940s and was approved by the FDA for depression in 1959 and for enuresis in 1973. PRESCRIPTION: Yes
SIDE EFFECTS: The most common side effects of imipramine are:
- increased heart rate,
- heart palpitations,
- blurred vision,
- difficulty urinating,
- dry mouth,
- weight gain or loss,
- hives, and
Quick GuideDepression Hurts: Physical Symptoms of Depression
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