- What is imipramine, and how does it work (mechanism of action)?
- What brand names are available for imipramine?
- Is imipramine available as a generic drug?
- What are the side effects of imipramine?
- What is the dosage for imipramine?
- Which drugs or supplements interact with imipramine?
- Is imipramine safe to take if I'm pregnant or breastfeeding?
- What else should I know about imipramine?
What is imipramine, and how does it work (mechanism of action)?
Imipramine is an antidepressant medication of the tricyclic class. Medications in this class are often referred to as tricyclic antidepressants or TCAs. Depression is defined as an all-pervasive sense of sadness and gloom. In patients with depression, abnormal levels of chemicals in the brain (called neurotransmitters) may be the cause of their depression. These neurotransmitters are chemicals that the nerves in the brain use to communicate with each other. Imipramine is believed to elevate mood by raising the levels of neurotransmitters in the brain. Imipramine was first synthesized in the late 1940s and was approved by the FDA for depression in 1959 and for enuresis in 1973. PRESCRIPTION: Yes
What brand names are available for imipramine?
Is imipramine available as a generic drug?
GENERIC AVAILABLE: Yes
What are the side effects of imipramine?
The most common side effects of imipramine are:
- increased heart rate,
- heart palpitations,
- blurred vision,
- difficulty urinating,
- dry mouth,
- weight gain or loss,
- hives, and
Other important side effects include:
- high blood pressure,
- low blood pressure when standing (orthostatic hypotension),
- heart attack,
- hepatitis, and
- abnormal heart beats
Imipramine also can cause elevated pressure in the eyes of some patients with glaucoma.
Following prolonged therapy with high doses, abrupt discontinuation of TCAs, including imipramine, could lead to withdrawal symptoms such as nausea, vomiting, diarrhea, or restlessness. Therefore, many experts recommend gradually reducing the dose of drug if the drug is to be discontinued.
Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of imipramine or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thinking or behavior, and unusual changes in behavior.
Quick GuidePhysical Symptoms of Depression in Pictures
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