imatinib, Gleevec (cont.)

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PREPARATIONS: Tablets: 100, and 400 mg

STORAGE: Imatinib should be stored at room temperature between 15 C - 30 C (59 F - 86 F).

DOSING: The recommended dose range is 300-800 mg orally daily depending on the condition being treated. All doses should be administered with a meal and a large glass of water. A dose of 800 mg should be administered as 400 mg twice daily. Doses less than 800 mg may be administered once daily. It can be dissolved in apple juice or water for those with difficulty swallowing.

DRUG INTERACTIONS: The blood concentration of imatinib may be increased by several drugs that reduce its break down by the liver. Examples include ketoconazole, itraconazole (Sporanox), clarithromycin (Biaxin), atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), saquinavir (Invirase), telithromycin (Ketek), voriconazole (Vfend), and grapefruit juice. Increased blood concentrations of imatinib may increase the occurrence of adverse effects.

Medically Reviewed by a Doctor on 5/18/2015

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