Phototoxic drug reaction. In phototoxic reactions, the drug may become activated by exposure to sunlight and cause damage to the skin. The skin's appearance resembles sunburn, and the process is generally has a fast onset. Ultraviolet A (UVA) radiation is most commonly associated with phototoxicity, but ultraviolet B (UVB) and visible light may also contribute to this reaction. Symptoms of phototoxic reaction may initially consist of a burning and stinging sensation; then redness occurs with in 24 hours of exposure to the sun in the exposed areas of the body. Common phototoxic drugs include certain antibiotics and antihistamines.