Image Collection: Vascular, Lymphatic and Systemic Conditions
- All (557)
- Allergic Skin Disorders (31)
- Viral Skin Diseases (26)
- Bacterial Skin Diseases (29)
- Fungal Skin Diseases (17)
- Bites and Infestations (27)
- Noncancerous, Precancerous and Cancerous Tumors (56)
- Diseases of Pigment (26)
- Papules, Scales, Plaques and Eruptions (47)
- Vascular, Lymphatic and Systemic Conditions (48)
- Scalp, Hair and Nails (26)
- Pregnancy Stages (9)
Pernicious anemia is a disease where large, immature, nucleated cells (megaloblasts, which are forerunners of red blood cells) circulate in the blood, and do not function as blood cells; it is a disease caused by impaired uptake of vitamin B-12 due to the lack of intrinsic factor (IF) in the gastric mucosa. It was termed "pernicious" because before it was learned that vitamin B-12 could treat the anemia, most people that developed the disease died from it.
In the image above, bone marrow aspirate is seen from a patient with untreated pernicious anemia. Megaloblastic maturation of erythroid precursors is shown. Two megaloblasts occupy the center of the slide with a megaloblastic normoblast above.
Guide to understanding the Image Collection categories: