Scalp, Hair and Nails

Picture of Nail-Patella Syndrome

Picture of Nail-Patella Syndrome
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Nail-patella syndrome. This entity, also known as hereditary osteo-onychodysplasia, is a genetic disease linked to a mutation in the gene encoding transcription factor LMX1B, mapped on the long arm of chromosome 9 (9q34). The manifestations include fingernail dysplasia, absent or hypoplastic patellae, the presence of posterior conical iliac horns, and abnormalities of the radial heads. Patients are also at risk for kidney disease and glaucoma.

    Image Source: Color Atlas of Pediatric Dermatology Samuel Weinberg, Neil S. Prose, Leonard Kristal Copyright 2008, 1998, 1990, 1975, by the McGraw-Hill Companies, Inc. All rights reserved.

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