iloperidone (Fanapt)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC NAME: iloperidone

BRAND NAME: Fanapt

DRUG CLASS AND MECHANISM: Iloperidone is an oral, atypical antipsychotic used to treat schizophrenia. Other atypical antipsychotic drugs include

Atypical antipsychotics differ from typical antipsychotics because they cause a lesser degree of movement (extrapyramidal) side effects and constipation.

The exact mechanism of action of iloperidone is not known, but like other anti-psychotics, it is believed that iloperidone affects the way the brain works by interfering with communication among the brain's nerves. Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on the nerves. The attachment of the neurotransmitters either stimulates or inhibits the function of the nearby nerves. iloperidone blocks several of the receptors on nerves including dopamine type 2, serotonin type 2, and alpha 2 adrenergic receptors. It is believed that many psychotic illnesses are caused by abnormal communication among nerves in the brain and that by altering communication through neurotransmitters, iloperidone can alter the psychotic state. Iloperidone was approved by the FDA in 2009.

PRESCRIBED FOR: Iloperidone is a prescription medicine used to treat schizophrenia in adults.

SIDE EFFECTS WARNING:

  • Iloperidone increases the risk of stroke and death in elderly patients with dementia-related psychosis. Iloperidone should not be used to treat dementia-related psychosis in elderly patients.
  • Like other antipsychotics, life-threatening neuroleptic malignant syndrome (NMS) may occur.
  • Life threatening abnormal heartbeats (arrhythmias) may occur.
  • Involuntary movement of the jaw (tardive dyskinesia) may occur.
  • Metabolic changes including high blood sugar (hyperglycemia), diabetes mellitus, increase in blood cholesterol, and weight gain are associated with atypical antipsychotics.
  • Iloperidone may cause orthostatic hypotension, which is a drop in blood pressure especially when standing up from a sitting or lying position.
  • A decrease in blood cell counts has been reported during treatment with iloperidone. Low white blood cell counts may increase the risk for infections.
  • Iloperidone may increase blood levels of prolactin, a hormone.
  • Iloperidone also may cause seizures.
  • Priapism (abnormal, prolonged penile erections) have been reported.
  • Patients who are at risk for suicide should be observed closely since antipsychotics have been associated with an increased risk of suicide.
Medically Reviewed by a Doctor on 11/6/2015

Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment

Schizophrenia: Symptoms, Types, Causes, Treatment
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