ibandronate, Boniva

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GENERIC NAME: ibandronate

BRAND NAME: Boniva

DRUG CLASS AND MECHANISM: Ibandronate is an oral and intravenous drug that is used for treating osteoporosis. It is a member of the bisphosphonate class of drugs which includes etidronate (Didronel), pamidronate (Aredia), risedronate (Actonel), and tiludronate (Skelid). Bone is in a constant state of remodeling. New bone is laid down by cells called osteoblasts while old bone is removed by cells called osteoclasts. Bisphosphonates strengthen bone by inhibiting bone removal (resorption) by osteoclasts. After menopause, there is an increased rate of bone loss leading to osteoporosis, and ibandronate has been shown to increase bone density and decrease fractures of bones. FDA approved ibandronate in May 2003.

GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 150 mg; Intravenous injection, 3 mg/3 ml

STORAGE: Ibandronate tablets should be stored at room temperature, 15-30 C (59-86 F).

PRESCRIBED FOR: Ibandronate is used to prevent and treat osteoporosis in women after menopause. The optimum duration of treatment has not been established and treatment should be evaluated periodically.

DOSING: The dose of ibandronate is 150 mg orally once monthly. The tablet should be taken on the same day of each month. Tablets should be taken at least 60 minutes before the first food or drink of the day (other than plain water) or before other oral medication, because of concern that that food or medication will interfere with the absorption of ibandronate. Absorption of ibandronate from the intestine is poor, and any potential further decrease in absorption by food or medications needs to be avoided.




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