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- What is ibandronate, and how does it work (mechanism of action)?
- What brand names are available for ibandronate?
- Is ibandronate available as a generic drug?
- Do I need a prescription for ibandronate?
- What are the uses for ibandronate?
- What are the side effects of ibandronate?
- What is the dosage for ibandronate?
- Which drugs or supplements interact with ibandronate?
- Is ibandronate safe to take if I'm pregnant or breastfeeding?
- What else should I know about ibandronate?
What is ibandronate, and how does it work (mechanism of action)?
- Ibandronate is an oral and intravenous drug that is used for treating osteoporosis. It is a member of the bisphosphonate class of drugs which includes etidronate (Didronel), pamidronate (Aredia), risedronate (Actonel), and tiludronate (Skelid). Bone is in a constant state of remodeling. New bone is laid down by cells called osteoblasts while old bone is removed by cells called osteoclasts. Bisphosphonates strengthen bone by inhibiting bone removal (resorption) by osteoclasts. After menopause, there is an increased rate of bone loss leading to osteoporosis, and ibandronate has been shown to increase bone density and decrease fractures of bones.
- FDA approved ibandronate in May 2003.
What brand names are available for ibandronate?
Is ibandronate available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for ibandronate?
What are the uses for ibandronate?
What are the side effects of ibandronate?
Some of the more common side effects of ibandronate include:
- Back pain
- Pain in the legs or arms
- Abdominal pain
- Stomach upset
- Tooth disorder
- Abnormal weakness
Other side effects include:
- Bone pain
- Joint pain
- Muscle pain
Possible serious side effects include:
- Respiratory tract infections
- Urinary tract infections (UTIs)
- Low-trauma femoral fractures
- High blood pressure
Low calcium levels may occur if calcium and vitamin D intake is not adequate. Severe irritation of the esophagus (for example, esophagitis, esophageal ulcers, esophageal erosions) can occur. This occurs more often when patients do not drink enough water with ibandronate, wait less than 60 minutes before lying down after taking ibandronate, or continue to take ibandronate after developing symptoms of esophageal irritation. Ibandronate should not be used by individuals with abnormalities of the esophagus.
Patients may experience jaw problems (osteonecrosis of the jaw) associated with delayed healing and infection after tooth extraction.
Quick GuideWhat Is Osteoporosis? Treatment, Symptoms, Medication
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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