Ruchi Mathur, MD, FRCP(C) is an Attending Physician with the Division of Endocrinology, Diabetes and Metabolism and Associate Director of Clinical Research, Recruitment and Phenotyping with the Center for Androgen Related Disorders, Department of Obstetrics and Gynecology at Cedars-Sinai Medical Center.
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Hypothyroidism, wherein the thyroid gland produces an inadequate amount of thyroid hormone, is a common disorder particularly in women of childbearing age.
Hypothyroidism of the mother during pregnancy may result in developmental delay in the child.
Treatment of hypothyroidism requires thyroid hormone medication.
There may be indications to start thyroid hormone therapy in women who are borderline in thyroid function and who are either pregnant or desiring pregnancy.
The treatment goal of hypothyroidism in pregnancy is to maintain a thyroid hormone level within high normal range.
Pregnant women who are on thyroid hormone should have blood testing frequently during pregnancy as requirements may change.
Early studies found that children born to mothers with hypothyroidism
during pregnancy had lower IQ and impaired psychomotor (mental and motor)
development. If properly controlled, often by increasing the amount of
thyroid hormone, women with hypothyroidism can have healthy, unaffected
Thyroid disease is particularly common in women of child-bearing age. As a result, it is no surprise that thyroid disease may complicate the course of pregnancy.
Frequency varies among different populations and different countries. While
pregnancy itself is a natural state and not a "disease," thyroid disorders during pregnancy affect mother and baby. This article focuses specifically on hypothyroidism and pregnancy. After a general description of normal and abnormal thyroid function, recent data on long term consequences in children of mothers who had hypothyroidism during pregnancy will be reviewed.
Thyroid peroxidase (TPO) is an enzyme made in the thyroid gland that is important in the production of thyroid hormone. TPO is found in thyroid follicle cells where it converts the thyroid hormone T4 to T3./"...