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February 9, 2012

Hypercalcemia
(Elevated Calcium Levels)

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Calcium Supplements: Not All Are Equal

Author: Betty Kovacs, MS, RD
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

Not all calcium supplements are the same, and taking too many calcium supplements can lead to hypercalcemia

Viewer Question: I've heard that not all calcium supplements are the same. Which over-the-counter vitamins or minerals help build bones? Which brands or types are better than others?

Dietician's Response: You heard right, not all calcium supplements are the same. The supplements will differ by the kinds of calcium that they contain, the amount that they contain, and any thing else that is added to them (other minerals or vitamins). Along with that, there are other factors that will affect how much of the calcium you will actually absorb, including medications that you are taking, your age, your vitamin D levels, the amount of calcium that you are taking and if you are pregnant. If you have any concerns over any of these, it would be best to speak with your physician before taking anything.

The most common forms of calcium in supplements are calcium carbonate and calcium citrate. The differences between the two are...

Hypercalcemia Introduction

Calcium is a mineral that is important in the regulation and processes of many body functions including bone formation, hormone release, muscle contraction, and nerve and brain function. Hypercalcemia is the term that refers to elevated levels of calcium in the bloodstream.

Regulation of Calcium

Calcium levels are tightly regulated in the body. Calcium regulation is primarily controlled by parathyroid hormone (PTH), vitamin D, and calcitonin.

  • Parathyroid hormone is a hormone produced by the parathyroid glands, which are four small glands that surround the thyroid and are found in the anterior part of the lower neck.

  • Vitamin D is obtained through a process that begins with sun exposure to the skin, the process then continues in the liver and kidneys. Vitamin D can also be found in foods such as eggs and dairy products.

  • Calcitonin is produced in specialized cells in the thyroid gland.

Together, these three hormones act on the bones, the kidneys, and the GI tract to regulate calcium levels in the bloodstream.

Picture of the Parathyroid Glands

Calcium Supplements: Not All Are Equal

Author: Betty Kovacs, MS, RD
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

Not all calcium supplements are the same, and taking too many calcium supplements can lead to hypercalcemia

Viewer Question: I've heard that not all calcium supplements are the same. Which over-the-counter vitamins or minerals help build bones? Which brands or types are better than others?

Dietician's Response: You heard right, not all calcium supplements are the same. The supplements will differ by the kinds of calcium that they contain, the amount that they contain, and any thing else that is added to them (other minerals or vitamins). Along with that, there are other factors that will affect how much of the calcium you will actually absorb, including medications that you are taking, your age, your vitamin D levels, the amount of calcium that you are taking and if you are pregnant. If you have any concerns over any of these, it would be best to speak with your physician before taking anything.

The most common forms of calcium in supplements are calcium carbonate and calcium citrate. The differences between the two are...

What are the causes of hypercalcemia?

One of the most common causes of high calcium levels (hypercalcemia), is an overproduction of parathyroid hormone, or hyperparathyroidism.

  • Hyperparathyroidism occurs in 25 out of every 100,000 persons and tends to be more common in women.

  • It can be the result of all four parathyroid glands producing too much PTH (parathyroid hyperplasia), or one gland specifically producing an excessive amount of hormone (usually the result of a parathyroid adenoma, or benign tumor).

Hypercalcemia can occur due to other medical conditions. These conditions can vary in severity and chronicity, and may be life-threatening. Malignancy is a common cause of elevated blood calcium. Up to 20% of individuals with cancer will develop hypercalcemia at some point in their disease.

Other conditions associated with hypercalcemia include:



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Hypercalcemia (Elevated Calcium Levels)

Introduction

Primary hyperparathyroidism is a disorder of the parathyroid glands, also called parathyroids. "Primary" means this disorder originates in the parathyroids: One or more enlarged, overactive parathyroid glands secretes too much parathyroid hormone (PTH). In secondary hyperparathyroidism, a problem such as kidney failure causes the parathyroids to be overactive. This publication focuses on primary hyperparathyroidism.

What are the parathyroid glands?

The parathyroid glands are four pea-sized glands located on the thyroid gland in the neck. Occasionally, a person is born with one or more of the parathyroid glands embedded in the thyroid, in the thymus, or located elsewhere around this area. In most such cases, however, the glands function normally.

Though their names are similar, the thyroid and parathyroid glands are entirely different glands, each producing distinct hormones with specific functions. The p...

Read the Hyperparathyroidism article »






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