hyoscyamine, atropine, scopolamine and phenobarbital, Donnatal (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
STORAGE: Belladonna/phenobarbital should be stored at controlled room temperature between 15-30 C (59-86 F)
PRESCRIBED FOR: Belladonna/phenobarbital is used in the treatment of abdominal pain, bloating and cramps in patients with irritable bowel syndrome. It is also used in patients with acute inflammation of the stomach and intestines (gastroenteritis) to reduce pain and diarrhea. It is used occasionally as additional therapy in patients with duodenal ulcer.
DOSING: May be taken with or without food. The dosage is adjusted to the individual patient to assure control of symptoms with a minimum of side effects. The usual doses are 1-2 regular tablets 3 to 4 times daily or 1 extended release tablet every 8 or 12 hours or 5-10 ml of the elixir, 3 or 4 times daily.
DRUG INTERACTIONS: Phenobarbital reduces the blood levels of several drugs by increasing their breakdown in the body. Examples include voriconazole (Vfend), bocepravir (Victrelis), ranolazine (Ranexa), and protease inhibitors (for example, atazanavir [Reyataz], indinavir [Crixivan], saquinavir [Invirase], ritonavir [Norvir]). Belladonna/phenobarbital should not be combined with potassium tablets because belladonna/phenobarbital slows the passage of potassium tablets through the gastrointestinal tract, leading to potassium-induced ulcers and high potassium levels in the blood.
PREGNANCY: Use during pregnancy has not been adequately evaluated. Pregnant women should use belladonna alkaloid/phenobarbital only when the expected benefit outweighs the potential but unknown risks.
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