- The recommended oral dose of immediate release tablet or drops for treating irritable bowel syndrome, gastrointestinal disorders, or peptic ulcer disease is 0.125 mg to 0.25 mg every 4 hours.
- The maximum dose is 1.5 mg daily.
- The dose of immediate release formulations for treating hypermotility disorder is 0.15 to 0.3 mg orally every 6 hours.
- The risk of adverse effects increases when hyoscyamine is combined with other drugs that block the action of acetylcholine. Such drugs include antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants, or some antihistamines.
- Antacids may interfere with the absorption of extended release hyoscyamine.
PREGNANCY AND BREASTFEEDING SAFETY:
- It is not known whether hyoscyamine can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. It should only be given to pregnant women when it is clearly needed.
- Hyoscyamine is excreted in breast milk.
Quick GuideIBS - Irritable Bowel Syndrome: Symptoms, Diet, Treatment
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