hylan G-F 20 (Synvisc, Synvisc One)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is hylan G-F 20 (Synvisc, Synvisc One), and how does it work (mechanism of action)?

What is hylan G-F 20 (Synvisc, Synvisc One)?

Hylan G-F 20 (Synvisc, Synvisc One) is an injectable fluid that is used to treat osteoarthritis (OA) of the knee. Osteoarthritis is a type of arthritis in which the joints of the body degenerate and become painful and stiff. Osteoarthritis is the most common form of arthritis. Almost 10 million Americans suffer from the disease. Most people with OA are those 45 years old, and women. More women have OA than men.

How does Synvisc work?

Joints contain a fluid, called synovial fluid, which acts as a lubricant and shock absorber. Patients with osteoarthritis have synovial fluid that is thinner than normal, and, therefore, it is less effective as a lubricant and shock-absorber. Synvisc is an elastic fluid that is made from a substance called hyaluronan, that is found in normal joint fluid. Hyaluronan is the key substance in joint fluid that provides the shock-absorbing quality to the fluid, and it is essential for the proper functioning of joints. When Synvisc is injected into the knee of a patient with osteoarthritis, the drug helps to restore the shock-absorbing effect of the fluid within the knee. This can reduce pain, resulting in a more active lifestyle.

What are the uses for Synvisc?

Synvisc is used for treating pain caused by osteoarthritis of the knee.

What are the side effects of Synvisc?

About 1 in 14 persons experience pain or swelling in the injected knee, and one third of those who do, need to have fluid removed from the knee.

Common side effects include:

Other side effects include:

  • Injection site pain
  • Injection site stiffness
  • Injection site redness
  • Skin rash
  • Itching
  • Facial flushing
  • Facial swelling

Which drugs or supplements interact with Synvisc?

There are no known drug interactions with Sinvisc.

Medically Reviewed by a Doctor on 5/22/2017

Quick GuideOsteoarthritis (OA): Treatment, Symptoms, Diagnosis

Osteoarthritis (OA): Treatment, Symptoms, Diagnosis
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