hylan G-F 20, Synvisc

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

GENERIC NAME: hylan G-F 20

BRAND NAME: Synvisc, Synvisc-One



USES: Hylan G-F 20 is used for treating pain caused by osteoarthritis of the knee.

SIDE EFFECTS: About 1 in 14 persons experience pain or swelling in the injected knee, and one third of those who do, need to have fluid removed from the knee. Side effects include:

  • injection site pain,
  • injection site stiffness,
  • injection site redness,
  • skin rash,
  • itching,
  • facial flushing and
  • facial swelling.

PREPARATIONS: Injection: 16 mg/2 ml, 48 mg/6 ml

DRUG INTERACTIONS: There are no known drug interactions with hylan G-F 20.

PREGNANCY AND BREASTFEEDING SAFETY: No adequate studies have been done in pregnant women. The risks of hylan G-F 20 during breastfeeding are not known. It is not known if hylan G-F 20 is excreted into breast milk.

STORAGE: hyland G-F 20 should be stored at room temperature, below 86 F (30 C). Any unused solution should be thrown out. It should not be frozen.

DOSING: Hylan G-F 20 is injected into the knee by a health professional. A course of treatment consists of three injections with each injection seven days apart when using Synvisc. Alternatively Synvisc-One, which contains all 3 doses (48 mg/ 6 ml) can be injected once as a single injection. Most people experience the greatest amount of relief from pain 8 to 12 weeks after beginning treatment. Some patients will require more than one course of treatment.


  • Hylan G-F 20 is an injectable fluid that is used to treat osteoarthritis of the knee. Osteoarthritis is a type of arthritis in which the joints of the body degenerate and become painful and stiff.
  • Osteoarthritis is the most common form of arthritis; almost 10 million Americans suffer from osteoarthritis. Most affected persons are over 45 years of age, and women are more often affected than men.
  • Joints contain a fluid, called synovial fluid, which acts as a lubricant and shock absorber. Patients with osteoarthritis have synovial fluid that is thinner than normal, and, therefore, it is less effective as a lubricant and shock-absorber.
  • Hylan G-F 20 is an elastic fluid that is made from a substance called hyaluronan, that is found in normal joint fluid.
  • Hyaluronan is the key substance in joint fluid that provides the shock-absorbing quality to the fluid, and it is essential for the proper functioning of joints.
  • When injected into the knee of a patient with osteoarthritis, hylan G-F 20 helps to restore the shock-absorbing effect of the fluid within the knee. This can reduce pain, resulting in a more active lifestyle.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 1/15/2016

Quick GuideOsteoarthritis (OA): Treatment, Symptoms, Diagnosis

Osteoarthritis (OA): Treatment, Symptoms, Diagnosis
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