hydroxyzine, Vistaril, Atarax (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
DOSING: Hydroxyzine has its maximal effect about 30 to 60 minutes after it is taken. Its effects last for 4 to 6 hours.
The recommended dose for treating itching (pruritus) is 25 mg given 3 or 4 times daily by mouth or by intramuscular injection. When used for sedation, the recommended dose is 50 to 100 mg orally or 25 to 100 mg by intramuscular injection. Anxiety and tension are managed with 50 to 100 mg in 4 divided doses or 50-100 mg intramuscular injection in 4 or 6 divided doses. Alcohol withdrawal is treated with a 50-100 mg injection and may be repeated every 4 to 6 hours as needed. The dose for nausea and vomiting is 25 to 100 mg by injection.
Hydroxyzine can be taken with or without food.
GENERIC AVAILABLE: Yes
Tablets: 10, 25, 50 and 100 mg. Capsules: 25, 50 mg. Syrup: 10 mg per teaspoonful (5mL). Suspension: 25 mg per teaspoonful (5mL). Injection: 25 and 50 mg/ml
STORAGE: Capsules, tablets, and liquids should be stored at room temperature 15 C to 30 C (59 F to 86 F). Liquid should not be frozen and should be shaken well prior to each use. Injectable hydroxyzine should be stored below 30 C (86 F).
DRUG INTERACTIONS: Hydroxyzine adds to (exaggerates) the sedating effects of alcohol and other drugs that can cause sedation such as the benzodiazepine class of anti-anxiety drugs (for example, diazepam [Valium], lorazepam [Ativan], clonazepam [Klonopin], alprazolam [Xanax]), the narcotic class of pain medications and its derivatives (for example, oxycodone and acetaminophen [Percocet], hydrocodone/acetaminophen [Vicodin], hydromorphone [Dilaudid], codeine, propoxyphene [Darvon]), the tricyclic class of antidepressants (for example, amitriptyline [Elavil, Endep], imipramine [Tofranil], desipramine [Norpramin]), and certain antihypertensive medications (for example, clonidine [Catapres], and propranolol [Inderal]). Hydroxyzine can also intensify the drying effects of other medications with anticholinergic properties (for example, dicyclomine [Bentyl], bethanechol [Urecholine], Probanthine, amitriptyline [Elavil, Endep], and chlorpromazine [Thorazine]). When using these drugs, the dose of hydroxyzine may require reduction.
Medically Reviewed by a Doctor on 12/5/2014
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