Hydroxyurea may increase blood uric acid concentration. Although no specific dose adjustments are necessary with probenecid or sulfinpyrazone (Anturane), hydroxyurea should be used cautiously with uricosuric medications.
Use of hydroxyurea with didanosine (Videx, Videx EC), with or without stavudine (Zerit, Zerit XR), has been associated with an increased incidence of side effects including pancreatitis and peripheral neuropathy (nerve problems). In general, hydroxyurea is not recommended in HIV patients as decreased CD4 counts, decreased viral suppression, and increased risk of side effects has been reported.
PREGNANCY: Hydroxyurea can cause harm to the unborn baby and therefore, should not be used during pregnancy. Although there are no adequate and well-controlled studies in pregnant women, in animals studies hydroxyurea was found to cause birth defects.
NURSING MOTHERS: Hydroxyurea is secreted in human milk. Nursing should be stopped due to the potential for serious adverse reactions in the infant.
REFERENCE: FDA Prescribing Information.
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